Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
A Comprehensive Protein Interaction Map and Druggability Investigation Prioritized Dengue Virus NS1 Protein as Promising Therapeutic Candidate
Dengue Virus is a serious threat to human life worldwide and is one of the most dangerous vectorborne diseases causing thousands of deaths annually We constructed a comprehensive
Analytical Comparability to Evaluate Impact of Manufacturing Changes of ARX788, an Anti-HER2 ADC in Late-stage Clinical Development
Antibodydrug conjugates ADCs are a class of therapeutics that combines an antigenspecific antibody backbone with a potent cytotoxic payload resulting in an enhanced therapeutic index The US FDA has currently approved
Repurposing the Medicines for Malaria Venture’s COVID Box to Discover Potent Inhibitors of Toxoplasma Gondii, and in Vivo Efficacy Evaluation of Almitrine Bismesylate (MMV1804175) in Chronically Infected Mice
Toxoplasmosis is a disease that occurs in diverse ecosystems and has significant impacts on the health of humans domestic animals and wildlife Toxoplasma gondii the causative agent of toxoplasmosis is an obligate intracellular
Unconditioned and Conditioned Anxiolytic Effects of Sodium Valproate on Flavor Neophobia and Fear Conditioning
In three experiments with rats we analyzed the potential anxiolytic effects of sodium valproate an anticonvulsant drug that has shown additional pharmacodynamic effects in animal models including anxiolytic action
Leveraging Epigenomes and Three-dimensional Genome Organization for Interpreting Regulatory Variation
Understanding the impact of regulatory variants on complex phenotypes is a significant challenge because the genes and pathways that are targeted by such variants and the cell type context in which regulatory variants operate are typically unknown
Daptev: Deep Aptamer Evolutionary Modelling for Covid-19 Drug Design
Viruses contain deoxyribonucleic acid DNA or ribonucleic acid RNA but are incapable of selfreproduction and rely on commandeering the cells protein creation capabilities to reproduce After the viral protein has been successfully reproduced
LRT: Integrative Analysis of Scrna-seq and Sctcr-seq Data to Investigate Clonal Differentiation Heterogeneity
Cell trajectory inference aims to understand how cells differentiate which is a longstanding problem in developmental biology
Development of a Neural Network Model to Predict the Presence of Fentanyl in Community Drug Samples
Increasingly Fouriertransform infrared FTIR spectroscopy is being used as a harm reduction tool to provide people who use drugs realtime information about the contents of their substances However
Targeting AAV Vectors to the Central Nervous System by Engineering Capsid–receptor Interactions That Enable Crossing of the Blood–brain Barrier
Viruses have evolved the ability to bind and enter cells through interactions with a wide variety of cell macromolecules
A biologist’s guide to planning and performing quantitative bioimaging experiments
Technological advancements in biology and microscopy have empowered a transition from bioimaging as an observational method to a quantitative one
