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Research Insights

The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.

Development of an amplicon-based sequencing approach in response to the global emergence of mpox

The multicountry mpox outbreak concurrent with the ongoing Coronavirus Disease COVID pandemic further highlighted the need for genomic surveillance and rapid pathogen wholegenome sequencing

Clade-D auxin response factors regulate auxin signaling and development in the moss Physcomitrium patens

Auxin response factors ARFs are a family of transcription factors that are responsible for regulating gene expression in response to changes in auxin level

Mechanism of agonist-induced activation of the human itch receptor MRGPRX1

Masrelated Gproteincoupled receptors XX MRGPRXX are primatespecific receptors that are recently reported to be responsible for many biological processes including itch sensation pain transmission and inflammatory reactions

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner

Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus SARSCoV has the potential to reveal novel drug targets and further our understanding of Coronavirus Disease COVID

The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2

The continuing emergence of SARSCoV variants has highlighted the need to identify additional points for viral inhibition

Retrospective cohort observation on psychotropic drug-drug interaction and identification utility from 3 databases: Drugs.com®, Lexicomp®, and Epocrates®

Pharmacotherapy is necessary for many people with psychiatric disorders and polypharmacy is common The psychotropic drugdrug interaction DDI should be concerned and efficiently monitored by a proper instrument

Understanding target-specific effects of antidepressant drug pollution on molluscs: A systematic review protocol

The environmental prevalence of widely prescribed human pharmaceuticals that target key evolutionary conserved biomolecules present across phyla is concerning Antidepressants one of the most widely consumed pharmaceuticals globally

Evaluating pharmaceuticals and other organic contaminants in the Lac du Flambeau Chain of Lakes using risk-based screening techniques

Pharmaceuticals are recognized as aquatic contaminants of emerging concern CECs because they have been detected in surface waters around the world

Analysis of medical malpractice liability disputes related to novel antineoplastic drugs and research on risk prevention and control strategies

To investigate the general characteristics of litigation cases of medical malpractice liability disputes MMLDs related to novel antineoplastic drugs NADs

New drug submissions in Canada and a comparison with the Food and Drug Administration and the European Medicines Agency: Cross-sectional analysis

Health Canada posts the outcomes of all New Drug Submissions In some cases companies have withdrawn submissions or submissions have been rejected by Health Canada for new active substances NAS