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Research Insights

The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.

High-dose Oral Thiamine Versus Placebo for Chronic Fatigue in Patients With Primary Biliary Cholangitis: a Crossover Randomized Clinical Trial

Primary biliary cholangitis is a chronic inflammatory immunemediated liver disease ultimately leading to liver fibrosis cirrhosis and endstage liver disease PBC is a rare disease with approximately being women aged between

Biomarker Combination Predicting Imminent Relapse After Discontinuation of Biological Drugs in Patients With Rheumatoid Arthritis in Remission

Patients with rheumatoid arthritis had suffered persistent pain from joint inflammation for a long period culminating in joint deformity and miserable life until the advent of methotrexate Methotrexate showed very good effects in reducing

Antibody Desolvation With Sodium Chloride and Acetonitrile Generates Bioactive Protein Nanoparticles

Around of the FDA approved drugs in were therapeutic proteins and their approval for clinical use has since till accounted for an average of Currently most commercial protein therapeutics are administered intravenously

Loxapine Inhibits Replication of Hepatitis A Virus in Vitro and in Vivo by Targeting Viral Protein 2C

No antiviral drugs currently are available for treatment of infection by hepatitis A virus a causative agent of acute hepatitis a potentially lifethreatening disease Chemical screening of a smallcompound library using

Whole Genome Case-control Study of Central Nervous System Toxicity Due to Antimicrobial Drugs

Antimicrobial drugs are associated with central nervous system toxicity in some patients Wellknown examples are ototoxicity due to aminoglycosides encephalopathy and seizures caused by betalactam antibiotics

Robust Expansion of Phylogeny for Fast-growing Genome Sequence Data

Nextgeneration sequencing technology enables largescale exploration of the diversity and monitoring temporal evolution of organisms which often involve generating and analysing large numbers

Discovery and Characterization of Anti-cancer Peptides From a Random Peptide Library

Cellpenetrating peptides are comprised of amino acids that function as carrier molecules to transduce various cargo molecules across cell membranes In the recent past several potential anticancer therapeutic peptides

Efficacy and Safety of Eszopiclone Combined With Drug Therapy in the Treatment of Insomnia After Stroke: A Network Meta-analysis and Systematic Review

Stroke one of the most common diseases in the world is characterized by a high incidence rate recurrence rate disability rate and mortality The motor dysfunction cognitive dysfunction swallowing dysfunction

Machine Learning and Bioinformatic Analyses Link the Cell Surface Receptor Transcript Levels to the Drug Response of Breast Cancer Cells and Drug Off-target Effects

The aberrant overexpression of cell surface receptors distinguishes cancer cells from their normal counterparts and is implicated in oncogenesis CSRs encompassing receptor tyrosine kinases

Application of in-silico Drug Discovery Techniques to Discover a Novel Hit for Target-specific Inhibition of Sars-cov-2 Mpro’s Revealed Allosteric Binding With MAO-B Receptor

Coronaviruses are singlestranded RNA viruses and have been associated with a wide range of mild to severe respiratory disorders in humans Coronaviruses did cause two major pandemic outbreaks

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