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Research Insights

The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.

Application of in-silico Drug Discovery Techniques to Discover a Novel Hit for Target-specific Inhibition of Sars-cov-2 Mpro’s Revealed Allosteric Binding With MAO-B Receptor

Coronaviruses are singlestranded RNA viruses and have been associated with a wide range of mild to severe respiratory disorders in humans Coronaviruses did cause two major pandemic outbreaks

Genome-wide Analyses Reveal the Contribution of Somatic Variants to the Immune Landscape of Multiple Cancer Types

It has been well established that cancer cells can evade immune surveillance by mutating themselves Understanding genetic alterations in cancer cells that contribute to immune regulation could lead to better immunotherapy patient stratification

System Dynamics Model for an Agile Pharmaceutical Supply Chain During COVID‑19 Pandemic in Iran

Nowadays competition is essential in developing industries Due to the intense competitiveness in the pharmaceutical industries governments try to balance competition and economic growth

Single-cell Transcriptomic Analysis Reveals Rich Pituitary–immune Interactions Under Systemic Inflammation

As the master gland of the endocrine system and a key component in the hypothalamuspituitaryadrenal axis the pituitary releases several hormones to regulate numerous physiological functions such as development sexual maturation

Cas9 Degradation in Human Cells Using Phage Anti-CRISPR Proteins

CRISPR arrays contain fragments of DNA that bacteria use as defense against invading nucleic acids RNAguided CRISPRassociated nucleases identify invaders by first binding

Enteric Pharmacokinetics of Monomeric and Multimeric Camelid Nanobody Single-domain Antibodies

Enteric diseases substantially impact health in both human and veterinary medicine While modern sanitation methods largely control enteric disease in the developed world foodborne pathogens remain a major cause of disease

Genome-wide Association Studies on Coronary Artery Disease: a Systematic Review and Implications for Populations of Different Ancestries

We performed a systematic review on the th of October summarizing genomewide association studies on coronary artery disease while employing the GWAS Catalog as an independent database to support the search

Stemness Genes and Mir-1247-3P Expression Associate With Clinicopathological Parameters and Prognosis in Lung Adenocarcinoma

Lung cancer makes up onefourth of all cancerrelated mortality with the highest mortality rate among all cancers Despite recent scientific advancements in cancer therapeutics the year survival rate of lung adenocarcinoma

Investigating the Impact of Physical Activity on Mitochondrial Function in Parkinson’s Disease (PARKEX): Study Protocol for a Randomized Controlled Clinical Trial

Parkinsons disease is a disorder characterized by the progressive degeneration of dopaminergic neurons resulting in a deficiency of dopamine in the striatum in the basal ganglia PD patients experience both motor and nonmotor symptoms

GPC-100, a Novel CXCR4 Antagonist, Improves in Vivo Hematopoietic Cell Mobilization When Combined With Propranolol

Multiple myeloma is a leading hematological malignancy with an estimated cases in the United States and approximately cases worldwide each year Autologous Stem Cell Transplant

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