Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Predicting unknown binding sites for transition-metal-based compounds in proteins
Transitionmetalbased compounds are promising therapeutic agents particularly in cancer treatment However predicting the binding sites of such compounds remains a major challenge In this work we investigate the applicabilit
Cost-effectiveness of pre-emptive pharmacogenetic testing: An umbrella review
Consortia have been established and published pharmacogeneticspecific guidelines with pharmacotherapeutic recommendations While these consortia and their guidance addressed important information gaps
Dual-function enzyme acts as a global c-di-GMP sink and local anti sigma factor antagonist to drive cellular differentiation
Soil bacteria of the genus Streptomyces are natural producers of over twothirds of clinically used antibiotics Their ability to generate these valuable metabolites is tightly linked to a developmental program involving the transition
Exploring hypoxia-related genes as prognostic indicators in lung adenocarcinoma
Lung adenocarcinoma LUAD is a leading cause of cancerrelated mortality with hypoxia contributing to tumor progression and treatment resistance Identifying hypoxiarelated biomarkers could enhance prognosis and therapeutic strategies for LUAD
Knowledge gaps and positive attitudes toward adult vaccination among nursing students: A Cross-sectional study
Vaccination is one of the most effective publichealth measures yet adult coverage in Spain remains suboptimal due to misinformation and hesitancy
Systematic identification of pan-cancer single-gene expression biomarkers in drug high-throughput screens
Precision oncology relies on molecular biomarkers to stratify patients into responders and nonresponders to a given treatment
Integration of palliative care into phase I oncology trials: A qualitative interview study with patients, informal caregivers, and healthcare providers
Patients with advanced cancer participating in phase I clinical trials often face limited survival while experiencing significant symptom burden Despite evidence supporting early palliative care integration
Design and in silico evaluation of an mRNA vaccine against HTLV-1 using AI-driven reverse vaccinology approaches
Human Tlymphotropic virus type HTLV is the first discovered human oncogenic retrovirus that can cause adult Tcell leukemialymphoma
Evaluation and enhancement of suspected opioid overdose definitions in emergency medical services data using machine learning with natural language processing
Fatal and nonfatal drug overdoses have evolved into a critical public health crisis with over a increase in the rate of fatal drug overdose since Emergency Medical Services EMS data has advantages
Occupational risk factors for depression and anxiety symptoms: Insights from a large cohort study during and after the SARS-CoV-2 pandemic
An increased risk for an occupationrelated SARSCoV infection has been linked to higher psychological distress This online survey investigates the prevalence of depressive and anxiety symptoms in a large sample
