Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Development of niosomal nanoparticles loaded with cisplatin and vorinostat combination for cancer therapy
Cisplatin CIS remains a cornerstone of chemotherapy but is limited by resistance and systemic toxicity Combining DNAdamaging agents with epigenetic modulators such as vorinostat VOR offers
Linking spatial drug heterogeneity to microbial growth dynamics in theory and experiment
Drugs play a central role in limiting bacterial population spread yet laboratory studies typically assume wellmixed environments when assessing microbial drug responses In contrast bacteria
Hierarchical analysis of RNA secondary structures with pseudoknots based on sections
Predicting RNA structures containing pseudoknots remains computationally challenging due to high processing costs and complexity While standard methods for pseudoknot prediction require ON
Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations
The ability of genomic inversions to reduce recombination and generate linkage can have a major impact on genetically based phenotypic variation in populations
Multi-omics analysis and functional validation of CHEK1 as an independent prognostic biomarker in Pancreatic cancer
Pancreatic cancer is a highly aggressive tumor with a poor prognosis due to challenging early diagnosis and limited treatment options
Cross-linking mass spectrometry for structure analysis of the intrinsically disordered Tau and phosphorylated Tau protein
We present a novel method for analyzing the folding of intrinsically disordered proteins IDPs such as Tau and phosphorylated Tau pTau in solution Using crosslinking mass spectrometry XLMS combined
TCR2HLA: Calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes
T cell receptors TCRs recognize peptides presented by polymorphic human leukocyte antigen HLA molecules but HLA genotype data are often missing from TCR repertoire sequencing studies
GAN-enhanced machine learning and metabolic modeling identify reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma is one of the deadliest forms of cancer presenting significant clinical challenges due to poor prognosis and limited treatment options Understanding the metabolic reprogramming
How much genetic information in RNA form can be protected by a CCMV virus-like particle?
The capsid protein of cowpea chlorotic mottle virus CCMV has been used extensively for in vitro packaging of heterologous RNA The associated viruslike particles VLPs are spherical
Single-cell alternative polyadenylation analysis reveals mechanistic insights of COVID-19-associated neurological and psychiatric effects
COVID is associated with increased risks of neurological and psychiatric sequelae Alternative polyadenylation APA is ubiquitous in human genes resulting in mRNA diversity and has been validated to play a pivotal regulatory
