Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Insights Into the Computer-aided Drug Design and Discovery Based on Anthraquinone Scaffold for Cancer Treatment: a Protocol for Systematic Review
Cancer remains one of the leading causes of deaths globally The worldwide cancer burden is constantly on the rise and in estimation the number of cancer cases will reach million in year as compared to million cases in year
Determination of Drug-related Problems Among Type 2 Diabetes Outpatients in a Hospital in Vietnam: a Cross-sectional Study
Drugrelated problems DRPs are common in clinical practice and occur at all stages of the medication process The major factor contributing to DRPs is prescription
Significant Expansion of the Donor Pool Achieved by Utilizing Islets of Variable Quality in the Production of Allogeneic “neo-islets”, 3-D Organoids
A globally available therapeutic that reestablishes insulin independence in patients with Type Diabetes while also not requiring potentially toxic antirejection drugs is urgently needed in order to improve
Nanograms of SARS-CoV-2 Spike Protein Delivered by Exosomes Induce Potent Neutralization of Both Delta and Omicron Variants
The emergence of severe acute respiratory syndrome coronavirus SARSCoV has created an urgent need for vaccine development strategies to produce safe effective readily available and accessible vaccines
Application of in Vitro Transcytosis Models to Brain Targeted Biologics
Due to the global increase in agerelated central nervous system CNS diseases there is substantial demand for new CNS medicines Biologics has become the new trend for CNS drug discovery Despite the large number of candidates
Discovery of Novel RARα Agonists Using Pharmacophore-based Virtual Screening, Molecular Docking, and Molecular Dynamics Simulation Studies
Nuclear retinoic acid receptors are liganddependent transcription factors involved in various biological processes such as embryogenesis cell proliferation differentiation reproduction and apoptosis
Tau Protein Aggregation Associated With SARS-CoV-2 Main Protease
The primary function of virus proteases is the proteolytic processing of the viral polyprotein These enzymes can also cleave host cell proteins which is important for viral pathogenicity modulation of cellular processes viral replication
Development of an in Vitro Aggregation Assay for Long Synthetic Polypeptide, Amyloidogenic Gelsolin Fragment AGElD187N 173–242
Gelsolin amyloidosis AGel amyloidosis is a hereditary systemic protein misfolding disease that is caused by mutations in the gelsolin gene The functional mutations predispose the secreted plasma gelsolin to aberrant proteolytic cleavages
Reduced Levels of A20 Protein Prompted RIPK1-dependent Apoptosis and Blood–brain Barrier Breakdown During Cerebral Ischemia Reperfusion Injury
The BBB is an anatomical and biochemical barrier that protects the brain from potentially harmful substances The BBB is a highly selective membrane barrier in the brain microvasculature that facilitates transport between the systemic circulation
Exploring the Potential of Approved Drugs for Triple-negative Breast Cancer Treatment by Targeting Casein Kinase 2: Insights From Computational Studies
Triplenegative breast cancer is an aggressive malignancy that requires effective targeted drug therapy In this study we employed in silico methods to evaluate the efficacy of seven approved drugs
