Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
A Case-control Study of Phosphodiesterase-5 Inhibitor Use and Alzheimer’s Disease and Related Dementias Among Male and Female Patients Aged 65 Years
There are currently only six FDAapproved therapies to treat Alzheimers disease cholinesterase inhibitors an nmethylDaspartate receptor antagonist
A Phase I Clinical Trial of Oncolytic Adenovirus Mediated Suicide and Interleukin-12 Gene Therapy in Patients With Recurrent Localized Prostate Adenocarcinoma
Approximately men are expected to be diagnosed with prostate cancer in USA in resulting in deaths Nearly onethird of patients will elect radiation therapy as their primary treatment
Therapeutic dosing and targeting efficacy of Pt-Mal-LHRH towards triple negative breast cancer
PtMalLHRH is a newly synthesized chemotherapeutic agent that was designed to selectively target the luteinizing hormonereleasing hormone LHRH receptor expressed by triple negative breast cancer
The Endocytic Receptor Protein LRP-1 Modulate P-glycoprotein Mediated Drug Resistance in MCF-7 Cells
Multidrug resistance is a major obstacle to successful cancer chemotherapy A typical form of MDR is due to the overexpression of membrane transport proteins such as GlycoproteinP resulting in an increased drug efflux preventing drug
Investigation of Evolutionary Dynamics for Drug Resistance in 3d Spheroid Model System Using Cellular Barcoding Technology
Complex evolutionary dynamics governing the drug resistance is one of the major challenges in cancer treatment Understanding these mechanisms requires a sequencing technology
Assessment of Antibody Dynamics and Neutralizing Activity Using Serological Assay After SARS-COV-2 Infection and Vaccination
The COVID antibody test was developed to investigate the humoral immune response to SARSCoV infection In this study we examined whether S antibody titers measured using the antiSARSCoV IgG II Quant assay
Meta-analysis of Outcomes From Drug-eluting Stent Implantation in Femoropopliteal Arteries
In recent years studies of drugeluting stent for femoropopliteal artery diseases have been gradually published To explore whether this type of stent is superior to the traditional bare metal stent
Bio-activity Prediction of Drug Candidate Compounds Targeting SARS-Cov-2 Using Machine Learning Approaches
The SARSCoV CLpro protein is one of the key therapeutic targets of interest for COVID due to its critical role in viral replication various highquality protein crystal structures
A Novel TOX3-WDR5-ABCG2 Signaling Axis Regulates the Progression of Colorectal Cancer by Accelerating Stem-like Traits and Chemoresistance
As the most common malignancy of the digestive system colorectal cancer CRC also remains one of the leading causes of cancerrelated deaths in both economically developed and developing countries
An in Vivo and in Silico Evaluation of the Hepatoprotective Potential of Gynura Procumbens: a Promising Agent for Combating Hepatotoxicity
The liver the most important metabolic organ of the body performs a wide variety of vital functions Hepatic cell injury occurs by the activation of reactive oxygen species ROS that are generated by carbon tetrachloride
