Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Chemical genomics informs antibiotic and essential gene function in Acinetobacter baumannii
The Gramnegative pathogen Acinetobacter baumannii poses a serious threat to human health due to its role in nosocomial infections that are resistant to treatment with current antibiotics
Development and comparison of single FLT3-inhibitors to dual FLT3/TAF1-inhibitors as an anti-leukemic approach
Acute myeloid leukemia AML is characterized by several recurrent mutations that affect disease biology and phenotype response to therapy and risk of subsequent relapse Though tyrosine kinase inhibitors
In vitro cellular interaction of drug-loaded liposomes with 2D and 3D cell culture of U87-MG cell line
The distinctive physiological and physical properties of D cultures that mimic tumor microenvironments in vivo make them more suitable for assessing the efficacy of drugs and nanoparticles compared to D culture models
Mutations in the Staphylococcus aureus Global Regulator CodY confer tolerance to an interspecies redox-active antimicrobial
Bacteria often exist in multispecies communities where interactions among different species can modify individual fitness and behavior Although many competitive interactions have been described molecular adaptations
ChromaFactor: Deconvolution of single-molecule chromatin organization with non-negative matrix factorization
The investigation of chromatin organization in single cells holds great promise for identifying causal relationships between genome structure and function
Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity
The human pathogens Plasmodium and Schistosoma are each responsible for over million infections annually especially in low and middleincome countries
Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics
Drugs targeting the ERresident innate immune receptor Stimulator of Interferon Genes STING are in development for treatments of cancer and inflammatory diseases Accurate determination of STING receptor levels
Formulation and evaluation of atorvastatin calcium trihydrate Form I tablets
Solid forms transformations and new crystal structures of an active pharmaceutical ingredient API can occur due to various manufacturing process conditions especially if the drug substance is formulated as a hydrate
Exploring potential drug targets for SLE through Mendelian randomization and network pharmacology
Systemic lupus erythematosus SLE is a complex and incurable autoimmune disease so several drug remission for SLE symptoms have been developed and used at present However treatment varies by patient and disease activity
Characterizing the regulatory effects of H2A.Z and SWR1-C on gene expression during hydroxyurea exposure in Saccharomyces cerevisiae
Chromatin structure and DNA accessibility are partly modulated by the incorporation of histone variants HAZ encoded by the nonessential HTZ gene in S
