Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
ChromaFactor: Deconvolution of single-molecule chromatin organization with non-negative matrix factorization
The investigation of chromatin organization in single cells holds great promise for identifying causal relationships between genome structure and function
Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity
The human pathogens Plasmodium and Schistosoma are each responsible for over million infections annually especially in low and middleincome countries
Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics
Drugs targeting the ERresident innate immune receptor Stimulator of Interferon Genes STING are in development for treatments of cancer and inflammatory diseases Accurate determination of STING receptor levels
Formulation and evaluation of atorvastatin calcium trihydrate Form I tablets
Solid forms transformations and new crystal structures of an active pharmaceutical ingredient API can occur due to various manufacturing process conditions especially if the drug substance is formulated as a hydrate
Exploring potential drug targets for SLE through Mendelian randomization and network pharmacology
Systemic lupus erythematosus SLE is a complex and incurable autoimmune disease so several drug remission for SLE symptoms have been developed and used at present However treatment varies by patient and disease activity
Characterizing the regulatory effects of H2A.Z and SWR1-C on gene expression during hydroxyurea exposure in Saccharomyces cerevisiae
Chromatin structure and DNA accessibility are partly modulated by the incorporation of histone variants HAZ encoded by the nonessential HTZ gene in S
The combined use of scRNA-seq and network propagation highlights key features of pan-cancer Tumor-Infiltrating T cells
Improving the selectivity and effectiveness of drugs represents a crucial issue for future therapeutic developments in immunooncology
Discovery of new drug indications for COVID-19: A drug repurposing approach
The outbreak of coronavirus health issues caused by COVIDSARSCoV creates a global threat to public health Therefore there is a need for effective remedial measures using existing and approved therapies
Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer’s drug discovery
Alzheimers disease AD is characterized by the aggregation of amyloid A peptides and the formation of plaques in the brain primarily derived from the proteolytic degradation of amyloid precursor protein APP
Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo
The SARSCoV pandemic alerted the potential for significant harm due to future crossspecies transmission of various animal coronaviruses to human
