Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
A novel DNA repair-independent role for Gen nuclease in promoting unscheduled polyploidy cell proliferation
Unscheduled whole genome duplication WGD also described as unscheduled or nonphysiological polyploidy can lead to genetic instability and is commonly observed in human cancers WGD generates DNA
Observational suspected adverse drug reaction profiles of fluoro-pharmaceuticals and potential mimicry of per- and polyfluoroalkyl substances (PFAS) in the United Kingdom
The aim of this research is to explore the suspected adverse drug reactions ADRs of perfluorinated medicines to determine whether side effects commonly associated with per and polyfluoroalkyl substances PFAS
Integrative molecular network analysis of genetic risk factors to infer biomarkers and therapeutic targets for rheumatoid arthritis
Understanding the interplay between genetic risk factors and molecular pathways in rheumatoid arthritis RA is essential for developing effective treatments This study aims to utilize genetic risk factors of RA and identify
Mechanistic modeling suggests stroma-targeting antibody-drug conjugates as an alternative to cancer-targeting in cases of heterogeneous target exspression
Antibodydrug conjugates ADCs are gaining increasing traction in the treatment of oncological diseases however many clinical failures have also been observed One key factor limiting ADC effectiveness is the heterogeneous expression
Single-cell mutational burden distributions in birth–death processes
Genetic mutations are footprints of cancer evolution and reveal critical dynamic parameters of tumour growth which otherwise are hard to measure in vivo The
Genetic inference of on-target and off-target side-effects of antipsychotic medications
It is often difficult to ascertain whether patientreported sideeffects are caused by a drug and if so through which mechanism Adverse sideeffects are the primary cause of antipsychotic drug discontinuation rather than poor efficacy
Enhanced genetic fine mapping accuracy with Bayesian Linear Regression models in diverse genetic architectures
We evaluated Bayesian Linear Regression BLR models with BayesC and BayesR priors as statistical genetic finemapping tools comparing their performance to established methods such as FINEMAP and SuSiE
Novel insights into post-myocardial infarction cardiac remodeling through algorithmic detection of cell-type composition shifts
Interpreting bulk RNA sequencing from heterogeneous tissues like the postmyocardial infarction MI heart is confounded by dynamic changes
Understanding disease-associated metabolic changes in human colonic epithelial cells using the iColonEpithelium metabolic reconstruction
The colonic epithelium plays a key role in the hostmicrobiome interactions allowing uptake of various nutrients and driving important metabolic processes To unravel detailed metabolic activities in the human
Randomization in clinical trials with small sample sizes using group sequential designs
Background Group sequential designs which allow early stopping for efficacy or futility may benefit from balanced sample sizes at interim and final analyses
