Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer’s drug discovery
Alzheimers disease AD is characterized by the aggregation of amyloid A peptides and the formation of plaques in the brain primarily derived from the proteolytic degradation of amyloid precursor protein APP
Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo
The SARSCoV pandemic alerted the potential for significant harm due to future crossspecies transmission of various animal coronaviruses to human There is a significant need of antibodybased drugs to treat patients infected
Repurposing of drug candidates against Epstein–Barr virus: Virtual screening, docking computations, molecular dynamics, and quantum mechanical study
EpsteinBarr virus EBV was the first tumor virus identified in humans and it is mostly linked to lymphomas and cancers of epithelial cells Nevertheless there is no FDAlicensed drug feasible for this ubiquitous EBV viral contagion
A novel small molecule screening assay using normal human chondrocytes toward osteoarthritis drug discovery
Osteoarthritis OA is the most common form of arthritis and a leading cause of pain and disability in adults A central feature is progressive cartilage degradation and matrix fragment formation driven by the excessive production
Ethosuximide-loaded bismuth ferrite nanoparticles as a potential drug delivery system for the treatment of epilepsy disease
Encapsulating antiepileptic drugs AEDs including ethosuximide Etho into nanoparticles shows promise in treating epilepsy Nanomedicine may be the most significant contributor to addressing this issue
Identifying crucial lncRNAs and mRNAs in hypoxia-induced A549 lung cancer cells and investigating their underlying mechanisms via high-throughput sequencing
Rapid proliferation and outgrowth of tumor cells frequently result in localized hypoxia which has been implicated in the progression of lung cancer The present study aimed to identify key long noncoding RNAs lncRNAs and messenger RNAs
An analysis of differential gene expression in peripheral nerve and muscle utilizing RNA sequencing after polyethylene glycol nerve fusion in a rat sciatic nerve injury model
Application of polyethylene glycol PEG to a peripheral nerve injury at the time of primary neurorrhaphy is thought to prevent Wallerian degeneration via direct axolemma fusion The molecular mechanisms of nerve fusion and recovery are unclear
Preclinical safety assessment of modified gamma globin lentiviral vector-mediated autologous hematopoietic stem cell gene therapy for hemoglobinopathies
Previously we reported the development of a human Aglobin gene lentivirus LV GbG which expresses high levels of HbF to correct the sickle cell anemia SCA phenotype in the Berkeley SCA mouse model and then modified
Radioprotective effect of the anti-diabetic drug metformin
Metformin is a biguanide currently used in the treatment of diabetes mellitus type Besides its antiglycemic effects metformin has been reported to induce different cellular pleiotropic effects depending on concentration and time of treatment
Unveiling Potent Inhibitors for Schistosomiasis Through Ligand-based Drug Design, Molecular Docking, Molecular Dynamics Simulations and Pharmacokinetics Predictions
Schistosomiasis is a neglected tropical disease which imposes a considerable and enduring impact on affected regions leading to persistent morbidity hindering child development diminishing productivity and imposing economic burdens
