Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
The Nottingham recovery from COVID-19 research platform (NoRCoRP): Functional, clinical and patient-reported outcomes in adults referred to a post-COVID respiratory service
To characterise symptoms function and patientreported outcome measures PROMs and identify associated factors in adults with persisting respiratory symptoms postCOVID
Predictive divergence in machine learning models for clinical mortality risk: A multicohort study of covid-19 patients
Machine learning ML algorithms are increasingly used in healthcare to support clinical decisionmaking While models with similar
Assessing the biopotency of the rAAV9 vector In Vitro
The potency assay is critical to ensure the effectiveness and consistency of recombinant Adenoassociated Virus AAV gene therapy vectors especially clinicalgrade products AAV serotype AAV
The synergistic interaction between ACE and TMPRSS2 polymorphisms increases the risk of severe COVID-19
Within a few years after the pandemic outbreak several of evidence have found to suggest that the genetic factors influence the severity and mortality rate of COVID
Protein-interaction network analysis reveals the role of Prp19 splicing factor in transcription of both intron-containing and intron-lacking genes
The process of transcription and cotranscriptional mRNA processing are facilitated by myriads of molecular interactions To elucidate the proteinprotein interactions
Safety population size and duration of exposure prior to approval of new medicines: A database analysis of medicines centralised approved in the European Union between 2011 and 2023
This study aims to analyse the number of patients who had been exposed to a new medicine before the approval by the European Commission EC as well as the number of patients studied longterm for chronic medication use
Development of niosomal nanoparticles loaded with cisplatin and vorinostat combination for cancer therapy
Cisplatin CIS remains a cornerstone of chemotherapy but is limited by resistance and systemic toxicity Combining DNAdamaging agents with epigenetic modulators such as vorinostat VOR offers
Linking spatial drug heterogeneity to microbial growth dynamics in theory and experiment
Drugs play a central role in limiting bacterial population spread yet laboratory studies typically assume wellmixed environments when assessing microbial drug responses In contrast bacteria
Hierarchical analysis of RNA secondary structures with pseudoknots based on sections
Predicting RNA structures containing pseudoknots remains computationally challenging due to high processing costs and complexity While standard methods for pseudoknot prediction require ON
Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations
The ability of genomic inversions to reduce recombination and generate linkage can have a major impact on genetically based phenotypic variation in populations
