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Research Insights

The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.

Optimal design of dose and drug pharmacokinetic characteristics to achieve the desired pharmacodynamic profile in repeated drug dosing

Oral drug therapy requires achieving a delicate balance between therapeutic efficacy and patient safety yet current dosing strategies often rely on empirical trialanderror methods that overlook the complex nonlinear dynamic

A genomic-led strategy to anticipate drug safety effects

Safetyrelated issues account for approximately of failures in new drug discovery programs On top of that many are discovered during postmarketing surveillance

Inhaled nitric oxide in fibrotic and advanced interstitial lung disease: A systematic review and meta-analysis of randomized controlled trials

Interstitial lung disease ILD can lead to pulmonary hypertension PH contributing to reduced exercise capacity in patients with ILD

The impact of cancer therapy-related oral complications on the quality of life and well-being of childhood cancer survivors: A scoping review

This study aimed to review the scientific literature on the effects of cancer treatmentrelated oral complications on the quality of life and wellbeing of children surviving cancer This study updates a previous

Predicting unknown binding sites for transition-metal-based compounds in proteins

Transitionmetalbased compounds are promising therapeutic agents particularly in cancer treatment However predicting the binding sites of such compounds remains a major challenge In this work we investigate the applicabilit

Cost-effectiveness of pre-emptive pharmacogenetic testing: An umbrella review

Consortia have been established and published pharmacogeneticspecific guidelines with pharmacotherapeutic recommendations While these consortia and their guidance addressed important information gaps

Dual-function enzyme acts as a global c-di-GMP sink and local anti sigma factor antagonist to drive cellular differentiation

Soil bacteria of the genus Streptomyces are natural producers of over twothirds of clinically used antibiotics Their ability to generate these valuable metabolites is tightly linked to a developmental program involving the transition