Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
CD38-targeted attenuated interferon alpha immunocytokine activates both innate and adaptive immune cells to drive anti-tumor activity
Recombinant interferon alpha IFN has been used to treat cancer patients for over years however its clinical utility has been limited by a narrow therapeutic index Given the recognized antitumor and immunomodulatory impacts
Exploring the molecular basis of the genetic correlation between body mass index and brain morphological traits
Several studies have demonstrated significant phenotypic and genetic correlations between body mass index BMI and brain morphological traits derived from structural magnetic resonance imaging sMRI
TRIM21 modulates stability of pro-survival non-coding RNA vtRNA1–1 in human hepatocellular carcinoma cells
Recent studies expanded our knowledge of diverse prosurvival functions of short noncoding vault RNAs One of the human vault RNA paralogs vtRNA modulates several intracellular processes including proliferation
Molecular simulation-based investigation of thiazole derivatives as potential LasR inhibitors of Pseudomonas aeruginosa
Pseudomonas aeruginosa P aeruginosa a very resilient pathogen demonstrates a diverse array of virulence factors the expression of which is closely linked to the quorum sensingQS mechanism
Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways
Genomewide association studies have identified thousands of common variants associated with an increased risk of neurodegenerative disorders However the noncoding localization of these variants has made the assignment
Unknotting RNA: A method to resolve computational artifacts
RNA D structure prediction often encounters entanglements computational artifacts that complicate structural models resulting in their exclusion from further studies despite the potentially accurate prediction of regions outside the entanglement
Chemical genomics informs antibiotic and essential gene function in Acinetobacter baumannii
The Gramnegative pathogen Acinetobacter baumannii poses a serious threat to human health due to its role in nosocomial infections that are resistant to treatment with current antibiotics
Development and comparison of single FLT3-inhibitors to dual FLT3/TAF1-inhibitors as an anti-leukemic approach
Acute myeloid leukemia AML is characterized by several recurrent mutations that affect disease biology and phenotype response to therapy and risk of subsequent relapse Though tyrosine kinase inhibitors
In vitro cellular interaction of drug-loaded liposomes with 2D and 3D cell culture of U87-MG cell line
The distinctive physiological and physical properties of D cultures that mimic tumor microenvironments in vivo make them more suitable for assessing the efficacy of drugs and nanoparticles compared to D culture models
Mutations in the Staphylococcus aureus Global Regulator CodY confer tolerance to an interspecies redox-active antimicrobial
Bacteria often exist in multispecies communities where interactions among different species can modify individual fitness and behavior Although many competitive interactions have been described molecular adaptations
