Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Biomarker Combination Predicting Imminent Relapse After Discontinuation of Biological Drugs in Patients With Rheumatoid Arthritis in Remission
Patients with rheumatoid arthritis had suffered persistent pain from joint inflammation for a long period culminating in joint deformity and miserable life until the advent of methotrexate Methotrexate showed very good effects in reducing
Antibody Desolvation With Sodium Chloride and Acetonitrile Generates Bioactive Protein Nanoparticles
Around of the FDA approved drugs in were therapeutic proteins and their approval for clinical use has since till accounted for an average of Currently most commercial protein therapeutics are administered intravenously
Loxapine Inhibits Replication of Hepatitis A Virus in Vitro and in Vivo by Targeting Viral Protein 2C
No antiviral drugs currently are available for treatment of infection by hepatitis A virus a causative agent of acute hepatitis a potentially lifethreatening disease Chemical screening of a smallcompound library using
Whole Genome Case-control Study of Central Nervous System Toxicity Due to Antimicrobial Drugs
Antimicrobial drugs are associated with central nervous system toxicity in some patients Wellknown examples are ototoxicity due to aminoglycosides encephalopathy and seizures caused by betalactam antibiotics
Robust Expansion of Phylogeny for Fast-growing Genome Sequence Data
Nextgeneration sequencing technology enables largescale exploration of the diversity and monitoring temporal evolution of organisms which often involve generating and analysing large numbers
Discovery and Characterization of Anti-cancer Peptides From a Random Peptide Library
Cellpenetrating peptides are comprised of amino acids that function as carrier molecules to transduce various cargo molecules across cell membranes In the recent past several potential anticancer therapeutic peptides
Efficacy and Safety of Eszopiclone Combined With Drug Therapy in the Treatment of Insomnia After Stroke: A Network Meta-analysis and Systematic Review
Stroke one of the most common diseases in the world is characterized by a high incidence rate recurrence rate disability rate and mortality The motor dysfunction cognitive dysfunction swallowing dysfunction
Machine Learning and Bioinformatic Analyses Link the Cell Surface Receptor Transcript Levels to the Drug Response of Breast Cancer Cells and Drug Off-target Effects
The aberrant overexpression of cell surface receptors distinguishes cancer cells from their normal counterparts and is implicated in oncogenesis CSRs encompassing receptor tyrosine kinases
Application of in-silico Drug Discovery Techniques to Discover a Novel Hit for Target-specific Inhibition of Sars-cov-2 Mpro’s Revealed Allosteric Binding With MAO-B Receptor
Coronaviruses are singlestranded RNA viruses and have been associated with a wide range of mild to severe respiratory disorders in humans Coronaviruses did cause two major pandemic outbreaks
Genome-wide Analyses Reveal the Contribution of Somatic Variants to the Immune Landscape of Multiple Cancer Types
It has been well established that cancer cells can evade immune surveillance by mutating themselves Understanding genetic alterations in cancer cells that contribute to immune regulation could lead to better immunotherapy patient stratification
