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Research Insights

The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.

Statistical Designs for Assessing Interchangeability of Biosimilar Products

The increasing expiration of patents for various innovator biopharmaceutical and biotech products has prompted a growing interest among companies in obtaining regulatory approval for biosimilar products

RNAi Therapeutic Platforms for Lung Diseases

Yu Fujita Fumitaka Takeshita Kazuyoshi Kuwano and Takahiro Ochiya Division of Molecular and Cellular Medicine National Cancer Center Research Institute Tokyo Japan Division of Respiratory Diseases Department of Internal Medicine Jikei University School of Medicine Tokyo Japan

Publication of Clinical Trials Supporting Successful New Drug Applications: A Literature Analysis

Department of Clinical Pharmacy University of California San Francisco San Francisco California United States of America Department of Epidemiology and Biostatistics University of California San Francisco San Francisco California United States of America Division of General Internal Medicine University of California San Francisco San Francisco C...

Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting

Important support functions including promotion of tumor growth angiogenesis and invasion have been attributed to the different cell types populating the tumor stroma ie endothelial cells cancerassociated fibroblasts

Boosting BCG with Recombinant Modified Vaccinia Ankara Expressing Antigen 85A: Different Boosting Intervals and Implications for Efficacy Trials

Ansar A Pathan Clare R Sander Helen A Fletcher Ian Poulton Nicola C Alder Natalie E R Beveridge Kathryn T WhelanAdrian V S Hill Helen McShane Centre for Clinical Vaccinology and Tropical Medicine University of Oxford Churchill Hospita

Factors Associated with Findings of Published Trials of Drug-Drug Comparisons: Why Some Statins Appear More Efficacious than Others

Published pharmaceutical industrysponsored trials are more likely than nonindustrysponsored trials to report results and conclusions that favor drug over placebo Little is known about potential biases in drugdrug comparisons

Optimizing the Dose of Pre-Pandemic Influenza Vaccines to Reduce the Infection Attack Rate

Steven Riley Joseph T Wu Gabriel M Leung Background The recent spread of avian influenza in wild birds and poultry may be a precursor to the emergence of a like human pandemic Therefore stockpiles of human prepandemic vaccine targeted at avian strains are being consider