Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Albendazole Repurposing on VEGFR-2 for Possible Anticancer Application: In-silico Analysis
Cancer is most deadly disease in the world Cancer treatment is the most difficult task for researchers As a result researchers devote time and resources to discovering and developing new therapies for various cancers
Identification of Monotonically Expressed Long Non-coding RNA Signatures for Breast Cancer Using Variational Autoencoders
As breast cancer is a multistage progression disease resulting from a genetic sequence of mutations understanding the genes whose expression values increase or decrease monotonically across
Segregational Drift Hinders the Evolution of Antibiotic Resistance on Polyploid Replicons
The emergence of antibiotic resistance under treatment depends on the availability of resistance alleles and their establishment in the population Novel resistance alleles are encoded either in chromosomal or extrachromosomal genetic elements
Improving Prediction of Drug-target Interactions Based on Fusing Multiple Features With Data Balancing and Feature Selection Techniques
Drug discovery relies on predicting drugtarget interaction which is an important challenging task The purpose of DTI is to identify the interaction between drug chemical compounds and protein targets
Genetic Diversity and Drug Sensitivity Profile of Mycobacterium Tuberculosis Among Children in Ethiopia
Tuberculosis is among the oldest recorded human infection which continues to cause illness and death in humans despite the worldwide use of the Bacille Calmette Gurin vaccines and different antiTB drugs
TGM2, HMGA2, FXYD3, and LGALS4 genes as biomarkers in acquired oxaliplatin resistance of human colorectal cancer: A systems biology approach
Colorectal cancer is regarded as the third most commonly diagnosed cancer and the second leading reason for cancerrelated mortality worldwide with million new cases and million deaths during
Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy
Phosphoinositidedependent kinase is a master kinase of the protein A G and C family kinases that play important roles in regulating cancer cell proliferation survival and metabolism Besides phosphorylatingactivating AKT
Noncanonical Contribution of Microglial Transcription Factor NR4A1 to Post-stroke Recovery Through TNF mRNA Destabilization
Microglia are the resident macrophages in the brain which exert critical physiological functions during development and homeostasis such as scanning of the brain microenvironment remodeling of synapses
A Network Pharmacology Approach to Decipher the Total Flavonoid Extract of Dracocephalum Moldavica L. In the Treatment of Cerebral Ischemia- Reperfusion Injury
Stroke is one of the three major diseases affecting human health At present the domestic and foreign guidelines recommend the use of intravenous recombinant tissue plasminogen activator thrombolysis for recanalization in the acute phase
Supernatural Inhibitors to Reverse Multidrug Resistance Emerged by Abcb1 Transporter: Database Mining, Lipid-mediated Molecular Dynamics, and Pharmacokinetics Study
Carcinoma is often an incurable disease with approximately two million cases reported in alone Chemotherapy is one of the most widely used treatments even though remission is observed in only of cancer cases because neoplasm cells
