Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Reduced Levels of A20 Protein Prompted RIPK1-dependent Apoptosis and Blood–brain Barrier Breakdown During Cerebral Ischemia Reperfusion Injury
The BBB is an anatomical and biochemical barrier that protects the brain from potentially harmful substances The BBB is a highly selective membrane barrier in the brain microvasculature that facilitates transport between the systemic circulation
Exploring the Potential of Approved Drugs for Triple-negative Breast Cancer Treatment by Targeting Casein Kinase 2: Insights From Computational Studies
Triplenegative breast cancer is an aggressive malignancy that requires effective targeted drug therapy In this study we employed in silico methods to evaluate the efficacy of seven approved drugs
Albendazole Repurposing on VEGFR-2 for Possible Anticancer Application: In-silico Analysis
Cancer is most deadly disease in the world Cancer treatment is the most difficult task for researchers As a result researchers devote time and resources to discovering and developing new therapies for various cancers
Identification of Monotonically Expressed Long Non-coding RNA Signatures for Breast Cancer Using Variational Autoencoders
As breast cancer is a multistage progression disease resulting from a genetic sequence of mutations understanding the genes whose expression values increase or decrease monotonically across
Segregational Drift Hinders the Evolution of Antibiotic Resistance on Polyploid Replicons
The emergence of antibiotic resistance under treatment depends on the availability of resistance alleles and their establishment in the population Novel resistance alleles are encoded either in chromosomal or extrachromosomal genetic elements
Improving Prediction of Drug-target Interactions Based on Fusing Multiple Features With Data Balancing and Feature Selection Techniques
Drug discovery relies on predicting drugtarget interaction which is an important challenging task The purpose of DTI is to identify the interaction between drug chemical compounds and protein targets
Genetic Diversity and Drug Sensitivity Profile of Mycobacterium Tuberculosis Among Children in Ethiopia
Tuberculosis is among the oldest recorded human infection which continues to cause illness and death in humans despite the worldwide use of the Bacille Calmette Gurin vaccines and different antiTB drugs
TGM2, HMGA2, FXYD3, and LGALS4 genes as biomarkers in acquired oxaliplatin resistance of human colorectal cancer: A systems biology approach
Colorectal cancer is regarded as the third most commonly diagnosed cancer and the second leading reason for cancerrelated mortality worldwide with million new cases and million deaths during
Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy
Phosphoinositidedependent kinase is a master kinase of the protein A G and C family kinases that play important roles in regulating cancer cell proliferation survival and metabolism Besides phosphorylatingactivating AKT
Noncanonical Contribution of Microglial Transcription Factor NR4A1 to Post-stroke Recovery Through TNF mRNA Destabilization
Microglia are the resident macrophages in the brain which exert critical physiological functions during development and homeostasis such as scanning of the brain microenvironment remodeling of synapses
