Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Functional human genes typically exhibit epigenetic conservation
Recent DepMap CRISPRCas single gene disruptions have identified genes more essential to proliferation in tissue culture It would be valuable to translate these finding
Roadmap for the use of Base Editors to Decipher Drug Mechanism of Action
CRISPR base editors are powerful tools for largescale mutagenesis studies This kind of approach can elucidate the mechanism of action of compounds a key process in drug discovery
Multifunctional RNA-binding Proteins Influence mRNA Abundance and Translational Efficiency of Distinct Sets of Target Genes
RNAbinding proteins RBPs can regulate more than a single aspect of RNA metabolism We searched for such previously undiscovered multifunctionality within a set of RBPs by defining the predictive value of RBP abundance for the transcription and translation levels of known RBP target genes
RNA Editing Regulates lnc RNA Splicing in Human Early Embryo Development
RNA editing is a co or posttranscriptional modification through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after transcription Previous studies found that RNA editing may be critically involved in cancer and aging However the function of RNA editing in human early
Interpretable Machine Learning for High-dimensional Trajectories of Aging Health
We have built a computational model for individual aging trajectories of health and survival which contains physical functional and biological variables and is conditioned
Modeling the Onset of Symptoms of COVID-19 Effects of SARS-CoV-2 Variant
Identifying the order in which symptoms of infectious diseases appear can be valuable in early detection and differentiation of symptomatic infections This information can aid in implementing nonpharmaceutical interventions
Immunogenicity and Safety of Primary Fractional-dose Yellow Fever Vaccine in Autoimmune Rheumatic Diseases
Brazil faced a yellow feverYF outbreak in and vaccination was considered for autoimmune rheumatic disease patientsARD with low immune suppression due to YF high mortality Yellow feverYF is an infectious disease caused by a Flavivirus Flaviviridae family Severe cases may evolve to bleeding disorders
Microsimulation Based Quantitative Analysis of COVID-19 Management Strategies
Pandemic management requires reliable and efficient dynamical simulation to predict and control disease spreading The COVID SARSCoV pandemic is mitigated by several nonpharmaceutical interventions but it is hard to predict which of these are the most effective for a given population
A Simple Assay to Quantify Mycobacterial Lipid Antigen-specific T Cell Receptors in Human Tissues and Blood
T cell receptors TCRs encode the history of antigenic challenge within an individual and have the potential to serve as molecular markers of infection In addition to peptide antigens bound
Vaccine Equity: A fundamental imperative in the fight against COVID-19
On March WHO declared the outbreak of severe acute respiratory syndrome coronavirus SARSCoV a global pandemic Now almost years on COVID
