Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Virus-derived variation in diverse human genomes
Acquisition of genetic material from viruses by their hosts can generate interhost structural genome variation We developed computational tools enabling us to study virusderived structural variants SVs
The landscape of antibody binding in SARS-CoV-2 infection
The search for potential antibodybased diagnostics vaccines and therapeutics for pandemic severe acute respiratory syndrome coronavirus SARSCoV has focused
The impact of age on genetic risk for common diseases
Inherited genetic variation contributes to individual risk for many complex diseases and is increasingly being used for predictive patient stratification
Rare variants regulate expression of nearby individual genes in multiple tissues
The rapid decrease in sequencing cost has enabled genetic studies to discover rare variants associated with complex diseases and traits Once this association is identified
Bioinformatics prediction of differential miRNAs in non-small cell lung cancer
Nonsmall cell lung cancer NSCLC accounts for of all lung cancers The drug resistance of NSCLC has clinically increased This study aimed to screen miRNAs associated with NSCLC using bioinformatics analysis We hope that the screened miRNA can provide a research direction for the subsequent treatment
A patient-oriented research approach to assessing patients’ and primary care physicians’ opinions on trauma-informed care
To gather patients and primary care physicians PCP opinions on traumainformed Care TIC and to investigate the acceptability of recommendations developed by patient family and physician advisors
Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium
Biopharmaceutical products BPs encompass a diverse range of therapeutics used for the treatment of autoimmune diseases and cancer They include replacement factors cytokines monoclonal antibodies
DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines
DNA supercoiling is essential for all living cells because it controls all processes involving DNA In bacteria global DNA supercoiling results from the opposing activities of topoisomerase I which relaxes DNA and DNA gyrase which compacts DNA These enzymes are widely conserved sharing amino acid identity between the closely related
BADAN-conjugated β-lactamases as biosensors for β-lactam antibiotic detection
Lactam antibiotic detection has significant implications in food safety control environmental monitoring and pharmacokinetics study Here we report the development
Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors
The ataxia telangiectasia and Radrelated ATR protein kinase is a key regulator of the cellular response to DNA damage Due to increased amount of replication stress cancer
