Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
LPCAT1 enhances castration resistant prostate cancer progression via increased mRNA synthesis and PAF production
Our previously study shown that Lysophosphatidylcholine Acyltransferase LPCAT is overexpressed in castration resistant prostate cancer CRPC relative to primary prostate cancer PCa
A spectrum of verticality across genes
Lateral gene transfer LGT has impacted prokaryotic genome evolution yet the extent to which LGT compromises vertical evolution across individual genes and individual phyla
Oxidative stress antagonizes fluoroquinolone drug sensitivity via the SoxR-SUF Fe-S cluster homeostatic axis
The level of antibiotic resistance exhibited by bacteria can vary as a function of environmental conditions Here we report that phenazinemethosulfate PMS a redoxcycling compound RCC
Mathematical modeling of hepatitis C RNA replication, exosome secretion and virus release
Hepatitis C virus HCV is a major cause of acute and chronic hepatitis leading to severe complications Understanding the mechanisms of HCV replication and transmission is crucial for developing effective treatments
Cell death and biomass reduction in biofilms of multidrug resistant extended spectrum β-lactamase-producing uropathogenic Escherichia coli isolates by 1,8-cineole
Escherichia coli is the most frequent agent of urinary tract infections in humans The emergence of uropathogenic multidrugresistant MDR E coli strains that produce extended spectrum lactamases ESBL has created additional problems in providing adequate treatment of urinary tract infections We have previously reported the antimicrobial activity of ci...
A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19
The global coronavirus disease COVID pandemic caused by severe acute respiratory syndrome coronavirus SARSCoV has led to unprecedented social and economic consequences
Potential synergistic activity of quercetin with antibiotics against multidrug-resistant clinical strains of Pseudomonas aeruginosa
Development of drug resistance in opportunistic pathogens is one of the major healthcare challenges associated with infection management Combination therapy
Global gene network exploration based on explainable artificial intelligence approach
In recent years personalized gene regulatory networks have received significant attention and interpretation of the multilayer networks has been a critical issue
Evaluation of classification and forecasting methods on time series gene expression data
Time series gene expression data is widely used to study different dynamic biological processes Although gene expression datasets share many of the characteristics of time series
Relative expression of microRNAs, apoptosis, and ultrastructure anomalies induced by gold nanoparticles in Trachyderma hispida (Coleoptera: Tenebrionidae)
The extensive use of nanomaterials generates toxic effects on nontarget species and the ecosystem Although gold nanoparticles AuNPs are generally expected to be safe the recent study a
