Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
The role of memory in non-genetic inheritance and its impact on cancer treatment resistance
Intratumour heterogeneity is a leading cause of treatment failure and disease progression in cancer While genetic mutations have long been accepted as a primary mechanism
Targeted proteomics as a tool to detect SARS-CoV-2 proteins in clinical specimens
The rapid sensitive and specific detection of SARSCoV is critical in responding to the current COVID outbreak In this proofofconcept study we explored the potential of targeted mass spectrometry MS based proteomics for the detection of SARSCoV proteins in both research samples and clinical specimens
Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies
Understanding SARSCoV evolution and host immunity is critical to control COVID pandemics At the core is an armsrace between SARSCoV antibody and angiotensin
Probing T-cell response by sequence-based probabilistic modeling
With the increasing ability to use highthroughput nextgeneration sequencing to quantify the diversity of the human T cell receptor TCR repertoire the ability to use TCR
Novel EDGE encoding method enhances ability to identify genetic interactions
When choosing a traditional genetic encoding for single nucleotide polymorphisms SNPs assumptions are made about their genetic models such as additive dominant or recessive
MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells
Mammalian cells release different types of vesicles collectively termed extracellular vesicles EVs EVs contain cellular microRNAs miRNAs with an apparent potential to deliver their miRNA cargo to recipient cells to affect the stability of individual mRNAs and the cells transcriptome
Machine learning and deep learning techniques to support clinical diagnosis of arboviral diseases: A systematic review
Neglected tropical diseases NTDs primarily affect the poorest populations often living in remote rural areas urban slums or conflict zones Arboviruses are a significant NTD category spread by mosquitoes Dengue
High-throughput framework for genetic analyses of adverse drug reactions using electronic health records
Understanding the contribution of genetic variation to drug response can improve the delivery of precision medicine However genomewide association studies GWAS for drug response are uncommon and are often hindered by small sample sizes
Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells
While COVID vaccines targeting the Spike protein of SARSCoV have demonstrated efficacy in preventing infection there is still a need for therapeutics to manage the disease
Bioinformatic analysis identifies potential key genes of epilepsy
Epilepsy is one of the most common brain disorders worldwide It is usually hard to be identified properly and a third of patients are drugresistant Genes related to the progression and prognosis of epilepsy are particularly needed to be identified
