Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
A pharmaceutical monitoring system to assess the quality of antituberculosis drug products used in Mauritania
The quality of drug products may be affected from manufacture to dispensing particularly at high temperature and humidity as in Mauritania
Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis
Members of the gasdermin GSDM family are poreforming effectors that cause membrane permeabilization and pyroptosis a lytic proinflammatory type of cell death
Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome
The streptothricin natural product mixture also known as nourseothricin was discovered in the early s generating intense initial interest because of excellent gramnegative activity
MyosinA is a druggable target in the widespread protozoan parasite Toxoplasma gondii
Toxoplasma gondii is a widespread apicomplexan parasite that can cause severe disease in its human hosts
High-throughput phenotypic screen identifies a new family of potent anti-amoebic compounds
Entamoeba histolytica is a diseasecausing parasitic amoeba which affects an estimated million people worldwide particularly in socioeconomically vulnerable populations experiencing water sanitation issues
Concerted and Multidisciplinary Management of COVID-19 Drug Therapies During the First Two Epidemic Waves in a Tertiary Hospital in Marseille, France: Results of the Pharma-Covid Study
To evaluate the impact of local therapeutic recommendation updates made by the COVID multidisciplinary consultation meeting RCP at the Hpital Europen Marseille HEM through the description of the drug prescriptions for COVID during the first two waves of the epidemic
Amitriptyline’s Anticholinergic Adverse Drug Reactions–a Systematic Multiple-Indication Review and Meta-Analysis
Half the US population uses drugs with anticholinergic properties Their potential harms may outweigh their benefits Amitriptyline is among the most frequently prescribed anticholinergic medicinal products is used for multiple indications and rated as strongly anticholinergic Our objective was to explore and quantify anticholinergic adverse drug rea...
Mgae-dc: Predicting the Synergistic Effects of Drug Combinations Through Multi-channel Graph Autoencoders
Accurate prediction of synergistic effects of drug combinations can reduce the experimental costs for drug development and facilitate the discovery of novel efficacious combination therapies for clinical studies The drug combinations with high synergy scores are regarded as synergistic ones while those with moderate or low synergy scores are additi...
Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes
Ensuring high vaccination and even booster vaccination coverage is critical in preventing severe Coronavirus Disease COVID Among the various COVID vaccines currently in use the mRNA vaccines have shown remarkable effectiveness However systemic adverse events AEs such as postvaccination fatigue are prevalent following mRNA vaccination
A novel class of antimicrobial drugs selectively targets a Mycobacterium tuberculosis PE-PGRS protein
The continued spread of drugresistant tuberculosis is one of the most pressing and complex challenges facing tuberculosis management worldwide Therefore developing a new class of drugs is necessary and urgently needed to cope with the increasing threat of drugresistant tuberculosis This study aims to discover a potential new class of tuberculosis d...
