Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
An Update On The Role Of Intestinal Cytochrome P450 Enzymes In Drug Disposition
The most commonly utilized method for drug treatment is through oral administration However when drugs are taken orally a significant portion of them can be eliminated by the metabolic activity of intestinal cytochrome P
Loading Of Tacrolimus Containing Lipid Based Drug Delivery Systems Into Mesoporous Silica For Extended Release
A novel approach to designing sustainedrelease preparations of tacrolimus using mesoporous silica as a carrier material is presented in this study Previous studies focused on solid dispersion techniques
Electrohydrodynamic encapsulation of cisplatin in poly (lactic-co-glycolic acid) nanoparticles for controlled drug delivery
Researchers conducted a study on targeted delivery of toxic chemotherapy drugs like cisplatin using polymeric nanoparticles They achieved high efficiency encapsulation of cisplatin in nanoparticles
Exosomes As Therapeutic Drug Carriers And Delivery Vehicles Across Biological Membranes: Current Perspectives And Future Challenges
Exosomes are small intracellular membranebased vesicles with different compositions that are involved in several biological and pathological processes The exploitation of exosomes as drug delivery vehicles
In Situ Forming Hydrogels Based On Chitosan For Drug Delivery And Tissue Regeneration
In situ forming hydrogels with simple solgel transition are more practicable as injectable hydrogels for drug delivery and tissue regeneration Stateoftheart in situ gelling systems can easily and efficiently
Evaluation Of Three Amorphous Drug Delivery Technologies To Improve The Oral Absorption Of Flubendazole
This research investigates the efficacy of three amorphous technologies in improving the dissolution rate and oral bioavailability of flubendazole FLU The selected approaches include a standard spraydried
New Agents For The Treatment Of Drug-resistant Mycobacterium Tuberculosis
Abstract Inadequate dosing and incomplete treatment regimens coupled with the ability of the tuberculosis bacilli to cause latent infections that are tolerant of currently used drugs have fueled the rise of multidrugresistant tuberculosis MDRTB Treatment of MDRTB infections is a major clinical challenge that has few viable or effective solutions t...
Computational Approaches In Target Identification And Drug Discovery
Abstract In the big data era voluminous datasets are routinely acquired stored and analyzed with the aim to inform biomedical discoveries and validate hypotheses No doubt data volume and diversity have dramatically increased by the advent of new technologies and open data initiatives Big data are used across the whole drug discovery pipeline from...
A Review Of Global Initiatives To Fight Antibiotic Resistance And Recent Antibiotics' Discovery
Abstract Data from across the world have shown an overall decline in the antibiotic pipeline and continually rising resistance to all firstline and lastresort antibiotics The gaps in our knowledge of existing prevalence and mechanisms of antibiotic resistance ABR are all too well known Several decades of antibiotic abuse in humans animals and agri...
Investigation Of Salicylate Hepatic Responses In Comparison With Chemical Analogues Of The Drug
The hydroxybenzoic acid salicylate exhibits potential antihyperglycemic effects attributed to its influence on mitochondrial uncoupling activation of AMPactivated protein kinase AMPK and inhibition
