Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Critical parameters in targeted drug development: the pharmacological audit trail
Abstract The Pharmacological Audit Trail PhAT comprises a set of critical questions that need to be asked during discovery and development of an anticancer drug Key aspects include defining a patient population establishing pharmacokinetic characteristics providing evidence of target engagement pathway modulation and biological effect with proo...
Charge-reversal Nanoparticles: Novel Targeted Drug Delivery Carriers
Driven by remarkable advancements in materials chemistry and drug delivery researchers are currently working on the development of chargereversal nanocarriers with the ability to administer
Progress And Perspectives On Targeting Nanoparticles For Brain Drug Delivery
Abstract Due to the ability of the bloodbrain barrier BBB to prevent the entry of drugs into the brain it is a challenge to treat central nervous system disorders pharmacologically The development of nanotechnology provides potential to overcome this problem In this review the barriers to braintargeted drug delivery are reviewed including the BBB
PBPK Modeling And Simulation In Drug Research And Development
Physiologically based pharmacokinetic PBPK modeling and simulation offer a valuable approach for predicting how drugs behave in the human body based on preclinical data
Structure-based Drug Discovery For Prion Disease Using A Novel Binding Simulation
The accumulation of abnormal prion protein PrPSc converted from the normal cellular isoform of PrP PrPC is assumed to induce pathogenesis in prion diseases Therefore drug discovery studies for these diseases
Preparation And Application Of Functionalized Nano Drug Carriers
Abstract Objective Targeting at category memory characteristics and preparation methods of functionalized nano drugs preparation technology of functionalized nano drug carriers is studied and then important role of functionalized nano drug carrier in preparation of medicine is studied Methods
Challenges And Strategies In Anti-cancer Nanomedicine Development: An Industry Perspective
Transforming anticancer nanomedicines from preclinical proof of concept to demonstrating their therapeutic value in clinical settings presents significant challenges
Design of experiment based validated stability indicating RP-HPLC method of temozolomide in bulk and pharmaceutical dosage forms
We have successfully developed and validated a precise and stability indicating RPHPLC method for the determination of Temozolomide TMZ in both bulk samples and nanostructured lipid carriers
Ion-pairing HPLC methods to determine EDTA and DTPA in small molecule and biological pharmaceutical formulations
We have developed and validated ionpairing highperformance liquid chromatographyultraviolet HPLCUV methods for the quantification of ethylenediaminetetraacetic acid EDTA in Abilify
Temperature Excursion Management – A Novel Approach Of Quality System In Pharmaceutical Industry
Abstract Quality of pharmaceutical product largely depends upon by the environment controls during its storage and handling Each pharmaceutical product should be handled and stored under specified storage condition labelled on product information data sheet or product pack Hence the temperature excursions during receipt of raw materials manufactur...
