Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Spectrophotometric And Spectroscopic Studies On Charge Transfer Complexes Of Antifungal Drug Clotrimazole
Clotrimazole CLZ is an imidazole derivative which is therapeutically used as an antifungal drug The routine control analysis of CLZ requires rapid reliable accurate and precise methods for the quantification
Analytical Methods For Determination Of Terbinafine Hydrochloride In Pharmaceuticals And Biological Materials
Abstract Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of mycosessince It is highly effective in the treatment of determatomycoses The chemical and pharmaceutical analysis of the drug requires effective analytical methods for quality control and pharmacodynamic and pharmacokinetic studies Ever since i...
Renal Drug Transporters And Their Significance In Drug–drug Interactions
Abstract The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites Renal drug transporters which are primarily located in the renal proximal tubules play an important role in tubular secretion and reabsorption of drug molecules in the kidney Tubular secretion is characterized by high clearance capacities broad subs...
Effectiveness Of A Novel Cellular Therapy To Treat Multidrug-resistant Tuberculosis
We urgently need novel treatments for multidrugresistant tuberculosis MDRTB Autologous mesenchymal stromal cell MSC infusion is one such possibility due to its potential to repair
Evaluation Of Ion Exchange Processes In Drug-eluting Embolization Beads By Use Of An Improved Flow-through Elution Method
Abstract An improved method for evaluating drug release behaviour of drugeluting embolization beads DEBs was developed utilizing an openloop flowthrough system in which the beads were packed into an occlusive mass within the system and extracted with a flowing elution medium over time Glass beads were introduced into the beads mass in order to ens...
Spectrophotometric determination of Ethionamide in Pharmaceuticals using Folin-Ciocalteu reagent and Iron (III)-Ferricyanide as Chromogenic Agents
ETM in a sodium carbonate medium resulting in the formation of a bluecolored complex that can be measured at nm referred to as the Molybdenumtungsten blue method The second method known as the Prussian blue method
Discrete Event Simulation Modelling For Dynamic Decision Making In Biopharmaceutical Manufacturing
Abstract With the increase in demand for biopharmaceutical products industries have realised the need to scale up their manufacturing from laboratorybased processes to financially viable production processes In this context biopharmaceutical manufacturers are increasingly using simulationbased approaches to gain transparency of their current produ...
Antitubercular Drugs For An Old Target: GSK693 As A Promising InhA Direct Inhibitor
Isoniazid INH has long been a key drug in the treatment of tuberculosis TB but the emergence of resistance poses a significant challenge Resistance to INH is often associated with mutations in the enzyme KatG
Targeting Blood-brain-barrier Transcytosis – Perspectives For Drug Delivery
Abstract Efficient transcytosis across the bloodbrainbarrier BBB is an important strategy for accessing drug targets within the central nervous system CNS Despite extensive research the number of studies reporting successful delivery of macromolecules or macromolecular complexes to the CNS has remained very low In order to expand current research...
Thin Films As An Emerging Platform For Drug Delivery
Pharmaceutical researchers worldwide are actively investigating the potential of thin films as an innovative approach to drug delivery These films offer an alternative to traditional dosage forms and are known for their convenience in swallowing
