Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
Orally Disintegrating Films: A Modern Expansion In Drug Delivery System
Over the past few decades tendency toward innovative drug delivery systems has majorly increased attempts to ensure efficacy safety and patient acceptability As discovery
Insights into CYP2B6-mediated drug–drug interactions
Emerging evidence indicates that the role of CYPB in human drug metabolism is more significant than previously understood The identification of numerous crucial substrates of CYPB along with the presence of polymorphic
Reprint Of “Mixed-Mode Chromatography In Pharmaceutical And Biopharmaceutical Applications”
MMC offers significant advantages in separating compounds that are challenging to retain or resolve using conventional reversedphase LC methods particularly for polar and charged molecules
Patient Perceptions Concerning Clinical Trials In Oncology Patients
Abstract Background Clinical trials are critical to scientifically evaluate promising new therapies in oncology but patient accrual to these studies is persistently low Patient preference plays an important role in enrollment in these trials We performed this survey to evaluate the perceptions of newly di
Distribution Of Bacterial Contamination In Non-sterile Pharmaceutical Materials And Assessment Of Its Risk To The Health Of The Final Consumers Quantitatively
Abstract Bacterial contamination control in pharmaceutical products is a critical aspect in the field of drug manufacturing industry due to the encountered risk to the patients health and possibly their life The application of commercial bacterial identification system is crucial to identify the type of contamination and its source to anticipate t...
Zika Virus Replicons For Drug Discovery
The current epidemic of Zika virus ZIKV has underscored the urgency to establish experimental systems for studying viral replication and pathogenesis and countermeasure development Here we report two ZIKV replicon systems
The Promises Of Quantitative Systems Pharmacology Modelling For Drug Development
Abstract Recent growth in annual new therapeutic entity NTE approvals by the US Food and Drug Administration FDA suggests a positive trend in current research and development RD output Prior to this the cost of each NTE was considered to be rising exponentially with compound failure occurring mainly in clinical phases Quantitative Systems Pharma
Temporal Trends And Factors Associated With Cardiovascular Drug Development, 1990 To 2012
Summary Cardiovascular disease remains a leading cause of death but stakeholders have recently raised concerns about the pace of innovation and investment in developing new therapeutics Here the authors characterized temporal trends in cardiovascular research and development over the past decades and the likelihood of successful completion of pre...
Recreational Drug Use In The Oslo Nightlife Setting: Study Protocol For A Cross-Sectional Time Series Using Biological Markers, Self-Reported And Qualitative Data
Introduction Recreational drug use in the nightlife setting carries the risk of many negative consequences such as violence injuries aberrant driving and sexual risktaking
Review On Potential Phytocompounds In Drug Development For Parkinson Disease: A Pharmacoinformatic Approach
Abstract Parkinsons disease PD is caused by human physiological function and is ranked as the second most common neurodegenerative disorder One of the prominent therapies currently available for PD is the use of dopamine agonists which mimic the natural action of dopamine in the brain and stimulate dopamine receptors directly Currently available p...
