Research Insights
The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.
In Silico Product Design Of Pharmaceuticals
Abstract The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms As the number of possible dosage forms may scale toward infinity their uniqueness requires a versatile production platform and numerical simulation in order to be manufactured efficiently A mathematical description of these syst...
Changing Paradigms In Bioequivalence Trials Submitted To The Ema For Evaluation – A Clinical And Regulatory Perspective
Abstract Background The selection of a robust bioequivalence BE study designs for registering a generic product remains still a hard task This task is still challenging despite the fact that generic products are much needed by health care providers in economical terms Thus BE study designs could be a means to
Validated Spectrometric Determination Of Penciclovir And Entecavir In Bulk And In Pharmaceutical Preparations
Abstract Simple rapid and sensitive spectroscopic methods were developed and validated for the determination of antiviral agents namely penciclovir PCV and entecavir ETV The first method is based on measuring the native fluorescence of each of the cited drugs at its optimum excitation and emission wavelengths The fluorescence intensity was measure...
Validation Of A Liquid Chromatographic Method For The Pharmaceutical Quality Control Of Products Containing Elacridar
Abstract Many anticancer drugs have an impaired bioavailability and poor brain penetration because they are substrates to drug efflux pumps such as Pglycoprotein and Breast Cancer Resistance Protein Elacridar is a strong inhibitor of these two drug efflux pumps and therefore has great potential to improve oral absorption and brain penetration of m...
Challenges Of Glycosylation Analysis And Control: An Integrated Approach To Producing Optimal And Consistent Therapeutic Drugs
The safety and effectiveness of therapeutic proteins are greatly influenced by glycosylation a process that adds sugar molecules to these proteins Numerous factors contribute to the glycosylation of biotherapeutics
Translational Medicine Guide Transforms Drug Development Processes: The Recent Merck Experience
Abstract Merck is implementing a questionbased Translational Medicine Guide TxM Guide beginning as early as lead optimization into its stagegate drug development process Initial experiences with the TxM Guide which is embedded into an integrated development plan tailored to each development program demonstrated opportunities to improve target unde...
Assessing The Potential Of Mathematical Modelling In Designing Drug-releasing Orthopaedic Implants
Abstract Orthopaedic implants have been the subject of intense research in recent years with academics clinicians and industrialists seeking to broaden our understanding of their function and potential consequences within the human body Current research is focussed on ways to improve the integration of an orthopaedic device within the body whether...
Evaluation Of Giardia Lamblia Thioredoxin Reductase As Drug Activating Enzyme And As Drug Target
The enzyme thioredoxin reductase TrxR known for its antioxidative properties has been proposed as a potential drug target for various pathogens including the protist parasite Giardia lamblia
Paradoxical Hypersusceptibility of Drug-resistant Mycobacterium tuberculosis to β-lactam Antibiotics
Mycobacterium tuberculosis M tuberculosis known for its innate resistance to lactam antibiotics exhibits variable susceptibility to lactamlactamase inhibitor combinations among clinical isolates
Cytokines In Cancer Drug Resistance: Cues To New Therapeutic Strategies
Abstract The development of oncoproteintargeted anticancer drugs is an invaluable weapon in the war against cancer However cancers do not give up without a fight They may develop multiple mechanisms of drug resistance including apoptosis inhibition drug expulsion and increased proliferation that reduce the effectiveness of the drug The collective...
