Drug Development
When to Consider Micronisation Early
How Particle Engineering Prevents Costly Bioavailability Failures in Phase I and Beyond
Micronization by spiral jet mill process is the first and the most effective process usually implemented or tested
The Evolution of mRNA Therapeutics
Recent Advances, Challenges, and the Path Forward
Scientists have debated the promise of mRNA as a therapeutic modality for over years Over this period the field has made great
Orchestrating a Commercially Successful Cell and Gene Therapy
The Role of Technology in Operational Scalability
The cell and gene therapy CGT landscape is rapidly evolving offering groundbreaking treatments for previously incurable diseases
Artificial Intelligence in Drug Development
Innovations and Challenges
Although Artificial Intelligence AI took root in the mid twentieth century shortly after the advent of computers
Accelerating the Drug Development Process
The bodys immune system exhibits a remarkable ability to scrutinize a cells interior a function of central importance
Blood to Plasma Ratio: An Important Determinant of the Pharmacokinetic Behavior of Drugs
The bloodtoplasma ratio BP ratio or Rb is an important parameter in pharmacokinetics PK that reflects the distribution of a drug between red blood cells RBCs and plasma
New Pharmacological Targets and Biomarkers for the Treatment of Tuberculosis (TB)
Mycobacterium tuberculosis MTB which has harmed people for more than decades is the cause of the chronic lung infectious disease known as pulmonary tuberculosis TB
Effective Biomarkers in Uncovering Novel Target Molecules for a Drug
The Revolution in New Drug Targets
Biological markers or the more commonly used term Biomarkers was first heard of in the s In the coming years this term gained unprecedented popularity as myriad studies were carried out regarding the efficacy of biomarkers in the drug discovery and development process as well as in the medical diagnosis of diseases
Model-Informed Drug Development (MIDD) - EMA's Advancement
MS is used in all phases of drug development in the EU US and UK starting from preclinical pharmacokinetic PK and pharmacokineticpharmacodynamics PKPD studies through clinical trials to postmarketing commitments
Human Vaccine Candidates Discovery and Development on Non-Animal Systems
An adoption with meaningful repercussions
A vaccine is traditionally a biological substance containing a harmless form of the causative organism that causes a particular disease It is usually given to healthy population by injection to prevent the contraction of the disease
