As the foundation for successful cell-based experiments, high-quality cell culture media directly impacts cell health, growth, and experimental reproducibility.
Sponsored by:
On Demand Webinars
Modern Requirements for Laboratory Balances
Density Determination Made Easy with the Quintix® Pro Standard Laboratory Balance
As analytical methods become more sensitive, even trace impurities can compromise data accuracy and reproducibility. Consistent, high-quality lab water is essential to preventing errors and avoiding costly rework.
Regulatory requirements for laboratory balances used in pharmaceutical analysis have undergone significant updates across major pharmacopoeias over the last years — including the USP (United States Pharmacopeia, latest version 07/2025), Ph. Eur. (European Pharmacopoeia, 07/2021, currently under revision), JP (Japanese Pharmacopoeia, 06/2024), and ChP (Chinese Pharmacopoeia, 03/2025).
Abzena is a Contract Design and Manufacturing Organisation (CDMO) focused on the development of complex biologics, including antibody-drug conjugates (ADCs) and bispecific antibodies.
In recent years, the regulatory requirements for balances used in pharmaceutical analysis have undergone significant updates across major pharmacopoeias — including the USP (United States Pharmacopeia, latest version 07/2025), Ph. Eur. (European Pharmacopoeia, 07/2021, currently under revision), JP (Japanese Pharmacopoeia, 06/2024), and ChP (Chinese Pharmacopoeia, 03/2025).
In an On Demand Webinar, Natali Hürlemann, Jr. Product Manager Software at Metrohm International Headquarters, and Lucas Foerster, Product Manager Lab Weighing at Sartorius, present a best practice example.
Discover how advanced pipetting techniques can enhance the repeatability and traceability of your pharmaceutical processes.
The webinar provides a detailed overview of the considerations and guidelines for conducting Fcγ receptor binding studies, particularly for IgG1, IgG2, and IgG4 monoclonal antibodies.
This webinar, led by Jim Palmer from Sartorius, Highlights the crucial role of lab balances in ensuring accurate analytical results.
Infographics
Picus® 2 electronic pipettes are the ideal tool to increase efficiency and precision across your workflows.
High-capacity analytical balances are essential for generating precise data that drive downstream analyses.
Discover everything you need to know about the updated ISO 8655:2022 standards for pipette-tip systems in our comprehensive infographic.
In the quest to understand human biology at a deeper level, organoids have emerged as a groundbreaking tool, offering a three-dimensional (3D), miniature representation of human organs.
Reduce environmental impact while achieving precision in lab weighing. Learn how sustainable design, energy efficiency, and responsible sourcing set the new standard for analytical balances.
In 2024, ISO 8655:2022 was expanded to include a new Part 10, providing essential guidelines for setting up an ISO-compliant laboratory environment. Learn how these updates affect your pipetting workflows.
The latest updates in ISO 8655:2022 Part 10 provide essential guidelines to enhance pipetting accuracy, compliance, and efficiency. This comprehensive resource will help you.
The cleaning of laboratory balances is vital in ensuring that contamination does not compromise lab weighing accuracy. In regulatory labs, the cleaning of balances often forms part of standard operating procedures (SOPs) to ensure compliance.
Lab balances play a critical role in workflows, due to the foundational data for downstream analytics
eBooks
Critical quality attributes (CQAs) are defined as a physical, chemical, biological, or microbiological property or characteristics that should be within an appropriate limit, range, or distribution to ensure the desired product quality.
Designing and performing assays that accurately measure the binding kinetics of biomolecular interactions can seem too specialized and out of reach for many researchers.
The field of real-time, label-free protein binding analysis has historically been marked with steep learning curves.
Pipettes play a critical role in the laboratory, as they are essential for the accurate delivery of samples and reagents in a wide range of experiments. Laboratories are facing increasing pressure to increase throughput, which has led to greater demand for pipettes that can facilitate more efficient workflows.
This comprehensive guide introduces cutting-edge technologies that are transforming the field!
Mesenchymal stem cells (MSCs) are a type of adult stem cell with the unique ability to develop into diverse cell types, including bone, cartilage, muscle, and fat. This regenerative capacity positions them as a powerful tool for addressing a range of musculoskeletal conditions.
Staying compliant with FDA 21 CFR Part 11 regulations is critical in pharmaceutical and life science laboratories. Yet, meeting requirements for electronic records and electronic signatures can be complex without the right tools.
In pharmaceutical quality control, even the smallest deviation can put safety, compliance, and product integrity at risk. That’s why precision in every step—from raw material verification to final product formulation—is essential.
Laboratory workflows demand precision, reliability, and compliance. The Cubis® II balance, combined with Sartorius’ powerful QApp software solutions, helps you achieve exactly that.
Explore how automation and live-cell technologies are revolutionizing 3D culture workflows for organoids and iPSCs.
Discover how image-based automation tools like CellCelector streamline single-cell isolation, boost productivity, and improve research outcomes. Download the free Sartorius ebook now.
Make smarter, more sustainable purchasing decisions with expert-backed insights.
Sterility testing is critical to ensuring that sterile products, such as pharmaceuticals and medical devices, are free of contaminating viable microorganisms.
Unlock the secrets to high-performing cell cultures with our comprehensive eBook, Mastering Advanced Cell Cultures.
Matching the ever-demanding regulatory needs of the pharmaceutical industry can be challenging and introducing fully compliant instrumentation and protocols into your lab is a huge step in the right direction.
White Papers
Current status from USP, Ph.Eur., JP, ChP
In this in-depth white paper from Sartorius, you will discover how live-cell monitoring and real-time imaging can optimize advanced cell culture workflows—without disturbing your samples.
Drug development is predicated on the identification of therapeutic targets, typically proteins or nucleic acids, that play a causal role in a disease and are ‘druggable’, i.e., amenable to pharmacological action by the drug.
Optimize Lab Efficiency, Accuracy, and Compliance for Electronic Pipettes and Lab Balances
The global biopharmaceutical market is rapidly growing, with small and midsize organizations outpacing large organizations in market share growth.
This white paper summarizes what has changed with the latest revisions in the major global standards,United States Pharmacopeia (USP), European Pharmacopoeia (Ph.Eur.), Japanese Pharmacopoeia (JP), and Chinese Pharmacopoeia (ChP).
Developing biosimilars requires rigorous analytical characterization to ensure safety, efficacy, and regulatory approval.
Every laboratory measurement carries some level of uncertainty—but in regulated environments, uncontrolled variation can compromise compliance, data integrity, and research outcomes.
Accurate weighing is fundamental to pharmaceutical quality and compliance. This white paper offers a detailed look into the requirements outlined in USP Chapters <41> and <1251> and European Pharmacopoeia Chapter 2.1.7, which govern how balances should be calibrated, tested, and operated in pharmaceutical labs. These standards are essential to ensuring that sample weights are accurate, repeatable, and traceable—critical to drug formulation, quality control, and regulatory audits.
The Cubis® II lab balances meets the rigorous compliance needs of modern pharmaceutical environments. With advanced modularity, seamless data handling, and full support for 21 CFR Part 11 and EU Annex 11, Cubis® II empowers labs to achieve data integrity, audit readiness, and operational efficiency—all by design.
When precision and compliance are non-negotiable, choosing accredited calibration services becomes essential. This white paper from Sartorius explores the value of ISO/IEC 17025-accredited calibration laboratories and how their certificates provide validated traceability to national and international standards.
When dealing with micro-quantities and strict regulatory demands, even small deviations in weighing can lead to significant errors. This expert white paper from Sartorius dives deep into the concept of minimum sample weight, a critical factor for ensuring weighing accuracy, process reliability, and compliance in pharmaceutical and laboratory environments.
Drug development and production is challenging. Avitide, based in Lebanon, New Hampshire, provides on-demand development and supply of high-performance affinity purification resins for the manufacture of biotherapeutic drug molecules.
A Cutting-Edge Model for Neurodegenerative Disease Studies
Discover expert insights on minimizing errors, optimizing balance placement, and ensuring high-precision weighing in your lab.
In recent years, biomedical research has transcended the limitations of 2D cell culture, paving the way for advanced models that deepen our understanding of developmental biology, disease mechanisms, and the development of more effective tissue-replacement therapies.
Brochures
Volumetric accuracy is fundamental to reliable research and diagnostics. The updated ISO 8655:2022 standards redefine calibration for piston-operated apparatus (POVA) such as pipettes and burettes, emphasizing integrated systems of pipettes and tips.
In biopharmaceutical and life science research, accuracy and reproducibility are non-negotiable. From cell and gene therapies to vaccines and antibody-drug conjugates, every step in R&D depends on precise weighing to ensure reliable outcomes.
In today’s regulated lab environments, data integrity is critical—not just for compliance, but for trust and efficiency. This white paper from Sartorius outlines how laboratories can meet the stringent requirements of FDA 21 CFR Part 11 and EU Annex 11 by embedding data integrity at the instrument level. Using the Cubis® II balance as a benchmark, the guide introduces a practical, checklist-driven approach to evaluate compliance, focusing on built-in features like secure access controls, electronic signatures, audit trails, and seamless system integration.
Biosimilar development is a rapidly growing field in the pharmaceutical industry. These regulated drug “reproductions” help to lower healthcare costs and increase access to vital medicines. However, the inherent complexity of producing a biologically active copy of a protein means that high similarity to the reference medicinal product is required.
Maintaining data integrity is critical for labs in today's regulatory environment. Non-compliance can result in costly delays, product recalls, and reputation risks. With our Data Integrity Compliance Checklist, you can:
Guidelines
The Ph.Eur. Chapter 2.1.7 specifies mandatory requirements for analytical balances, including calibration, performance testing and minimum sample weight.
This flyer provides essential tips for improving your pipetting results today. Learn about the importance of regular calibration, proper equipment maintenance, effective pipetting techniques, and the benefits of using electronic pipettes.
Stay ahead in your lab operations with our comprehensive guide to ISO 8655:2022-compliant pipette calibration. This resource is designed to help labs effectively manage, perform, and maintain accurate calibration
Understanding and adhering to the new ISO 8655:2022 standards is critical for laboratories working with piston-operated volumetric apparatus (POVA). Stay ahead with our comprehensive FAQ document that covers:
The Ph.Eur. Chapter 2.1.7 specifies mandatory requirements for analytical balances, including calibration, performance testing and minimum sample weight.
Discover how sustainable lab balances can reduce environmental impact while maintaining precision and efficiency.
Articles
Cell culture is a fundamental part of life science research. It’s so fundamental that we’ve probably all spent countless hours checking confluence, passaging cells and hoping for negative contamination tests.
In this interview, we address your ultrafiltration questions with Global Product Manager, John Cashman, focusing on practical solutions to enhance your laboratory workflows.
Pipette tips are indispensable in laboratories. Optifit standard tips offer versatility with various purity levels and packaging options, while Safetyspace® filter tips are pre-sterilized
Analytical weighing plays a crucial role in daily laboratory practices. In basic research, it usually serves as the first step in preparing buffers, media, and reagents.
Learn how labs worldwide are reducing waste, cutting carbon emissions, and making smarter choices for a sustainable future.
App Notes
Bispecific molecules are designed to bind two targets, but in practice one binding event can modulate the other. This application note shows how Octet BLI based assay formats enable a more quantitative functional characterization of bispecifics beyond a simple “binds/doesn’t bind” outcome.
Case Studies Using the iQue® HTS Platform
A Leap in Small Molecule Sensitivity
Uncover the secret to achieving unparalleled precision in your lab with the Cubis II Ultra-High Resolution Balances and its revolutionary Advantage Ionizer. Access our exclusive application note to unlock the strategies for mastering weighing in charged environments and transform your lab experience
Access our comprehensive application note, "Best Cleaning Practices for Cubis® II Balances," to unlock expert insights and recommendations for preserving the cleanliness and precision of your Sartorius laboratory balance.
Are you tired of struggling with imperfect laboratory conditions that affect the accuracy and precision of your analytical instruments? Look no further than the Cubis® II Ultra-High Resolution Balances from Sartorius.
Extracellular vesicles (EVs), particularly exosomes, have received significant attention in the field of diagnostics and therapeutics due to their role in transporting biomolecules.
Mesenchymal stem cells (MSCs) play a crucial role in regenerative medicine and cell therapy due to their ability to differentiate into multiple cell types and their immune modulatory properties.
Drug development using protein-based therapeutics has become particularly important in medical research and is predicated on the identification of therapeutic targets.
Cell line development involves the screening of thousands of clones to find those that are stable, produce high yields of the bio product and exhibit desired critical quality attributes (CQAs).
Considerable advancement in technology used in gene manipulation, editing and gene delivery has led to a rapid development of viable therapeutics based on gene therapy strategies.
Bioanalytical systems have rapidly developed over the past 10 years for lead selection during cell line development.
Fragment-based drug design (FBDD) has become a popular platform for the identification of lead candidates in drug discovery programs alongside structure-based drug design, and high throughput screening.
Biosensor-based real time label free interaction analysis using bio-layer interferometry (BLI) has become an indispensable tool in research and development for the selection and production of biologics that target a specific binding partner.
Learn how single-cell dissociation and multiparametric marker analysis can be applied to objectively assess brain organoid differentiation in a high-throughput workflow.
3D organoids and advanced cell models are powerful—but difficult to handle, monitor, and quantify.
Accurate segmentation of cell boundaries is the first and most critical step underlying the quantification of cell morphology.
Accurate assessment of mesenchymal stem cell (MSC) identity and differentiation is essential in both research and clinical applications—especially in the fast-moving field of regenerative medicine.
Octet® systems enable analytical assessment of biologics in various stages of the development workflow beginning with discovery and early selection to validation, manufacturing and quality control.
Demonstrating biosimilarity throughout upstream and downstream production processes is crucial. However, screening all potential candidates using standard analytical methods can be challenging. To overcome this, an alternative high-throughput analytical approach is needed. In this application note, we showcase the ability to rapidly test a Humira® biosimilar (adalimumab) development sample against three key ligands, meeting regulatory requirements.
A major mechanism of action for therapeutic monoclonal antibodies is the initiation of effector function via binding to Fc gamma receptors (FcγRs) expressed on the surface of immune effector cells. The ability of therapeutic monoclonal antibodies to bind FcγRs can greatly impact their safety and efficacy, and as such, efforts to analyze and enhance Fc interactions with FcγRs are an integral part of biotherapeutic development processes.
As the biosimilar market continues to expand, the need for efficient, cost-effective, and reliable development processes becomes paramount.
Advance Your In Vitro Studies with Growth Factors and Live-Cell Analysis