Critical quality attributes (CQAs) are defined as a physical, chemical, biological, or microbiological property or characteristics that should be within an appropriate limit, range, or distribution to ensure the desired product quality. These essential measurements include product-specific attributes such as size, charge, and glycosylation patterns as well as process-related impurities including host cell proteins (HCPs) and residual Protein A from chromatographic purification.

The advanced technology of Octet^® BLI systems enables the user to:

• Acquire real-time binding kinetics data to measure the rate of association (k_a), the rate of dissociation (k_d) and affinity constants (K_D)
• Measure up to 96 samples simultaneously with fully automated assays
• Rapidly identify optimal assay conditions using up to 96 channels for multiple conditions and reaction configurations in a single run
• Generate data from quantitation assays in real time
• Detect binding of a wide range of analytes, from small molecules to nanoparticles
• Recover precious or low-availability samples as binding reagents are not added directly to the sample and materials are minimally consumed.