Accurate determination of kinetics, affinity, titer, and other critical quality attributes (CQAs) is increasingly vital in bioprocessing, both in upstream and downstream applications. To meet the demands of high throughput and sensitivity, the development of systems for these purposes is crucial. These systems should enable assays to be conducted early in the workflow using unpurified samples, thereby facilitating faster time-to-results and enabling timely decision-making on lead candidates.

Among the various analytical tools available, bio-layer interferometry (BLI) and surface plasmon resonance (SPR) have gained wide acceptance and are extensively used in research, assay development, manufacturing, and QC. Analytes span from biological molecules such as biotherapeutics, vaccines, and diagnostic reagents to low molecular molecules as used in fragment-based drug discovery.

Sartorius is the only provider of both industry-leading label-free real time technologies, BLI and SPR.