EDITORIAL SECTION

Articles

Strategic Risk Management in Pharmaceutical Supply Networks

Ask a European pharmaceutical executive team how many qualified suppliers stand behind its ten highestvalue products and the answer arrives quickly and precisely Ask how many of those suppliers would still be shipping if a single industrial estate lost power for six weeks and the room falls silent That silence is the strategic problem in one sentence

Plant-derived Edible Nanoparticles in Delivering Cancer Drugs: Fact or Fad?

Plantderived edible nanoparticles PDENPs are nanosizedvesicles obtained from edible plants such as grapefruit curcumin ginger broccoli and lemon They contain miRNAs bioactive lipids and proteins which play an important role in cell signaling regulation of plant immunity and transport of bioactive molecules into mammalian cells As the world attempts to overcome

How Cloud Computing and AI Revolutionize Pharmaceutical Supply Chain Management

The pharma supply chain management has been considered as one of the most complicated spheres of operations in any industry As opposed to the traditional supply chain pharmaceutical supply chains have to juggle patient safety regulatory compliance cold chain integrity global sourcing and unpredictable demand and cost pressures simultaneously

Antibody-Drug Conjugates (ADCs): Driving the Next Generation of Precision Oncology

An antibodydrug conjugate is a targeted cancer therapy that links a potent cytotoxic drug to a monoclonal antibody through a chemical linker so the antibody delivers the payload directly to tumour cells expressing a chosen antigen The design widens the therapeutic window it concentrates cytotoxic activity where the target is expressed and limits the systemic exposure that constrains conventional c...

Chiral Biosensors: Precision Tools for Safer Drugs

The pharmaceutical industry has long been recognised the profound implications of chirality in drug design and development Enantiomers mirrorimage isomers of a chiral molecule show dramatically distinct pharmacokinetic PK and pharmacodynamic PD profiles One may be therapeutically active while its counterpart could be inactive or harmful As a result the precise detection discrimination and quantifi...

The Role of Biosimilars in the European Pharma Market: Advancements, Challenges, and Future Perspectives

The European pharmaceutical landscape has undergone remarkable transformations in recent years with the emergence of biosimilars playing a pivotal role in reshaping the industry Before delving into the intricacies of biosimilars

Techno Trends

Alume Biosciences Secures FDA Breakthrough Therapy Designation for Bevonescein

Alume Biosciences has received Breakthrough Therapy Designation BTD from the US Food and Drug Administration FDA for bevonescein an investigational fluorescent drug being developed to support realtime nerve visualisation during head and neck surgery in adults Bevonescein is an intravenous fluorescent peptidedye conjugate that binds to nerve tissue

Projects

SK pharmteco Plans More Than US$200 Million Investment in Small Molecule and Peptide Manufacturing

SK pharmteco is planning a fiveyear investment of more than US million to expand and modernise its pharmaceutical development and manufacturing operations in the United States The programme will strengthen capabilities for small molecules and peptides while supporting a more

Research Insights

A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG

PIGACDG is a congenital disorder of glycosylation caused by pathogenic partial lossoffunction variants in the PIGA gene PIGA encodes an enzyme responsible for the catalytic transfer of Nacetylglucosamine

whitepaper

Post-Translational Modifications in Drug Discovery: From Molecular Regulation to Clinical Impact

For decades the central dogma of molecular biology has anchored our understanding of cellular function DNA to RNA to protein But this linear view is incomplete A growing body of evidence shows that much of biologys