EDITORIAL SECTION

Articles

Fundamentals of Pharmaceutical Formulation Development

The process of changing an active drug substance into a safe and effective drug is much more complicated than it seems at first sight The core of this undertaking is pharmaceutical formulation development a science and strategic field that unites the pursuit of striking a scientific breakthrough and patient care Even the most promising drug molecule would not confer therapeutic benefits without be...

Mini-Tablets: A Valid Strategy to Combine Efficacy and Safety in Pediatrics

People respond very differently to medications depending on their weight age inborn capability to metabolize drugs the individual characteristics of the disease or the presence of comorbidities The wellknown assumption that one size fits all has clearly revealed all its limitations and become questionable Notably among humans pediatric patients represent

Pharmaceutical Business Strategy: Transformation, Regulation, Outsourcing and Growth

The pharmaceutical industry is standing at an unusual crossroads Patent cliffs are steeper regulators are tougher patients expect more transparency and payers are pushing back harder on price In this environment a strong Pharma Business Strategy is no longer a slide deck exercise for the boardroom its the difference between a company that scales globally and one that quietly fades into irrelevanc...

Role of Excipients in Drug Formulation: Functions, Types, and Applications

Whenever we consider medicines we tend to immediately jump into thinking about the active pharmaceutical ingredients APIs the substances that have therapeutic effects However APIs are not enough to develop stable effective and patientfriendly medicines This is where pharmaceutical excipients would come in The importance of excipients in the case of pharmaceuticals can go well beyond the level

Revolutionizing Healthcare: Gene Editing for Genetic Disorders with CRISPR Technology

Gene editing using CRISPR Clustered Regularly Interspaced Short Palindromic Repeats technology has the potential to revolutionize healthcare particularly in addressing genetic disorders

Medical Devices and Pharma: A Symbiotic Relationship for Improved Healthcare

The healthcare industry is continually evolving driven by technological advancements and innovative approaches to patient care Among the most significant developments is the symbiotic relationship between medical devices

Techno Trends

Alume Biosciences Secures FDA Breakthrough Therapy Designation for Bevonescein

Alume Biosciences has received Breakthrough Therapy Designation BTD from the US Food and Drug Administration FDA for bevonescein an investigational fluorescent drug being developed to support realtime nerve visualisation during head and neck surgery in adults Bevonescein is an intravenous fluorescent peptidedye conjugate that binds to nerve tissue

Projects

SK pharmteco Plans More Than US$200 Million Investment in Small Molecule and Peptide Manufacturing

SK pharmteco is planning a fiveyear investment of more than US million to expand and modernise its pharmaceutical development and manufacturing operations in the United States The programme will strengthen capabilities for small molecules and peptides while supporting a more

Research Insights

A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG

PIGACDG is a congenital disorder of glycosylation caused by pathogenic partial lossoffunction variants in the PIGA gene PIGA encodes an enzyme responsible for the catalytic transfer of Nacetylglucosamine

whitepaper

Post-Translational Modifications in Drug Discovery: From Molecular Regulation to Clinical Impact

For decades the central dogma of molecular biology has anchored our understanding of cellular function DNA to RNA to protein But this linear view is incomplete A growing body of evidence shows that much of biologys