EDITORIAL SECTION

Articles

The Impact of Inflation and New Policies on Drug Pricing

Drug pricing has long been a contentious issue balancing the cost of innovation and the need for accessible healthcare In recent years the landscape has grown more complex due to rising inflation

Single-Use Technologies: Accelerating Flexible Biopharmaceutical Manufacturing

For most of the past two decades the case for singleuse technologies in biopharmaceutical manufacturing was argued in the language of the plant Disposable bags and flow paths removed cleaninplace and steaminplace loops shortened turnarounds and allowed engineers to stand up a suite without a validation campaign measured in seasons That argument has been won Disposable systems now appear at every s...

Strengthening Clinical Trials Through Digital and Decentralized Technologies

For most of the past halfcentury the clinical trial has been organised around the investigator site Participants travelled to hospitals data were recorded at the clinic and monitors travelled again to verify them That model produced the evidence behind modern medicine but it asks a great deal of the people it depends on patients who must take time off work arrange care for dependants and cross reg...

The Role of Automation in Pharmaceutical Manufacturing

Modern pharmaceutics gained momentum through technological progress which primarily involved automation in pharmaceutical production processes The drug development process now produces major changes in drug manufacturing pipeline operations from start to finish delivery to marketplaces The pharmaceutical industry requires better efficiency together with precision and speed and therefore automation...

The Rise of Bioprinting: Opportunities and Challenges for Personalized Sterile Dosage Forms

Personalized medicine also known as precision medicine has gained significant traction in recent years transforming the healthcare landscape By considering an individuals unique genetic molecular and environmental factors personalized medicine aims to provide targeted therapies that maximize treatment effectiveness while minimizing adverse effects This approach

The Rise of Personalized Medicine in Europe: Opportunities and Challenges for Pharma Companies

In Europe there is a growing momentum around personalized medicine an inventive method that customizes medical treatments based on individual characteristics As progress in genomics and molecular diagnostics advances

Techno Trends

Alume Biosciences Secures FDA Breakthrough Therapy Designation for Bevonescein

Alume Biosciences has received Breakthrough Therapy Designation BTD from the US Food and Drug Administration FDA for bevonescein an investigational fluorescent drug being developed to support realtime nerve visualisation during head and neck surgery in adults Bevonescein is an intravenous fluorescent peptidedye conjugate that binds to nerve tissue

Projects

SK pharmteco Plans More Than US$200 Million Investment in Small Molecule and Peptide Manufacturing

SK pharmteco is planning a fiveyear investment of more than US million to expand and modernise its pharmaceutical development and manufacturing operations in the United States The programme will strengthen capabilities for small molecules and peptides while supporting a more

Research Insights

A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG

PIGACDG is a congenital disorder of glycosylation caused by pathogenic partial lossoffunction variants in the PIGA gene PIGA encodes an enzyme responsible for the catalytic transfer of Nacetylglucosamine

whitepaper

Post-Translational Modifications in Drug Discovery: From Molecular Regulation to Clinical Impact

For decades the central dogma of molecular biology has anchored our understanding of cellular function DNA to RNA to protein But this linear view is incomplete A growing body of evidence shows that much of biologys