EDITORIAL SECTION

Articles

Why Europe Is Becoming a Strategic Hub for Advanced API Manufacturing

For most of the past three decades API manufacturing was treated as a line item to be minimised Molecules moved east margins improved and European sites were consolidated sold or quietly retired The logic was sound as long as global supply chains behaved predictably They no longer do Pandemicera disruptions recurring shortages of antibiotics and other essential medicines

Pharmaceutical Business Strategy: Transformation, Regulation, Outsourcing and Growth

The pharmaceutical industry is standing at an unusual crossroads Patent cliffs are steeper regulators are tougher patients expect more transparency and payers are pushing back harder on price In this environment a strong Pharma Business Strategy is no longer a slide deck exercise for the boardroom its the difference between a company that scales globally and one that quietly fades into irrelevanc...

The Synergy of Bioinformatics and Computational Biology in Genome Analysis

In the dynamic field of biological sciences the fusion of bioinformatics and computational biology has catalyzed a paradigm shift in genome analysis This synergistic collaboration harnesses cuttingedge computational tools statistical models

The Role of Technology in Drug Anti-Counterfeiting Efforts

With the rise of drug counterfeiting posing a serious threat to global public health the role of technology in anticounterfeiting efforts has become increasingly vital As counterfeit drugs continue to infiltrate the market

Strategic Risk Management in Pharmaceutical Supply Networks

Ask a European pharmaceutical executive team how many qualified suppliers stand behind its ten highestvalue products and the answer arrives quickly and precisely Ask how many of those suppliers would still be shipping if a single industrial estate lost power for six weeks and the room falls silent That silence is the strategic problem in one sentence

Digital Bioprocessing: AI and Automation in Biologics Manufacturing

For most of the modern biologics era a mammalian cell culture batch was managed the way a ship is navigated in fog a fixed course periodic position checks and very little ability to correct midvoyage Operators set a feed strategy pulled offline samples once or twice a day and waited for the analytics to say whether the batch had drifted By the time a titre shortfall or a glycosylation shift appear...

Techno Trends

Alume Biosciences Secures FDA Breakthrough Therapy Designation for Bevonescein

Alume Biosciences has received Breakthrough Therapy Designation BTD from the US Food and Drug Administration FDA for bevonescein an investigational fluorescent drug being developed to support realtime nerve visualisation during head and neck surgery in adults Bevonescein is an intravenous fluorescent peptidedye conjugate that binds to nerve tissue

Projects

SK pharmteco Plans More Than US$200 Million Investment in Small Molecule and Peptide Manufacturing

SK pharmteco is planning a fiveyear investment of more than US million to expand and modernise its pharmaceutical development and manufacturing operations in the United States The programme will strengthen capabilities for small molecules and peptides while supporting a more

Research Insights

A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG

PIGACDG is a congenital disorder of glycosylation caused by pathogenic partial lossoffunction variants in the PIGA gene PIGA encodes an enzyme responsible for the catalytic transfer of Nacetylglucosamine

whitepaper

Post-Translational Modifications in Drug Discovery: From Molecular Regulation to Clinical Impact

For decades the central dogma of molecular biology has anchored our understanding of cellular function DNA to RNA to protein But this linear view is incomplete A growing body of evidence shows that much of biologys