EDITORIAL SECTION

Articles

Building Resilient Pharma Supply Chains to Strengthen Patient Care

The failure to deliver a temperaturesensitive biologic or a critical maintenance drug on time is becoming a patient outcome crisis not just an operational inefficiency By fortifying our global logistics networks we proactively safeguard the availability of lifesaving therapies and essential healthcare supplies securing the healthcare industrys central promise to global health This strategic impera...

Why is Pharmacogenetics and Pharmacogenomics Important?

In a world of increasingly personalized medicine the fields of pharmacogenetics and pharmacogenomics are gaining importance These disciplines explore the relationship between an individuals genetic makeup

Drug Safety in Focus: Challenges and Solutions for Pharma Companies

Drug safety is a paramount concern for pharmaceutical companies worldwide Ensuring the safety and efficacy of medications is not only a legal requirement but also a moral obligation towards patient welfare

Rethinking Make-or-Buy: Strategic Manufacturing Decisions in Pharma

Few strategic decisions in pharmaceutical operations carry as much longterm consequence as the choice of what to make and what to buy and few are revisited as rarely Network footprints agreed a decade ago partners selected during a capacity crunch technology transfers completed under launch pressure these choices harden into architecture They stop looking like decisions and start looking like the...

Nanosizing: An Enthralling Strategy to Improve the Systemic Availability of Poorly Soluble Drugs

To enable the effective preclinical testing efficacy and safety evaluation followed by firstinman studies formulation scientists must come up with effective strategies to achieve the desired bioavailability of these poorly soluble compounds

Beyond Manual Literature Screening: From AI Automation to Decision Preparation in Pharmacovigilance in Europe

As of August the EU AI Act is generally applicable although some obligations for highrisk AI systems apply at later dates For pharmacovigilance organisations a key consideration is to determine the role and classification of each AI system under the Act rather than assuming that AI used in PV is automatically classified as highrisk AIliteracy requirements are already applicable while provider and...

Techno Trends

Alume Biosciences Secures FDA Breakthrough Therapy Designation for Bevonescein

Alume Biosciences has received Breakthrough Therapy Designation BTD from the US Food and Drug Administration FDA for bevonescein an investigational fluorescent drug being developed to support realtime nerve visualisation during head and neck surgery in adults Bevonescein is an intravenous fluorescent peptidedye conjugate that binds to nerve tissue

Projects

SK pharmteco Plans More Than US$200 Million Investment in Small Molecule and Peptide Manufacturing

SK pharmteco is planning a fiveyear investment of more than US million to expand and modernise its pharmaceutical development and manufacturing operations in the United States The programme will strengthen capabilities for small molecules and peptides while supporting a more

Research Insights

A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG

PIGACDG is a congenital disorder of glycosylation caused by pathogenic partial lossoffunction variants in the PIGA gene PIGA encodes an enzyme responsible for the catalytic transfer of Nacetylglucosamine

whitepaper

Post-Translational Modifications in Drug Discovery: From Molecular Regulation to Clinical Impact

For decades the central dogma of molecular biology has anchored our understanding of cellular function DNA to RNA to protein But this linear view is incomplete A growing body of evidence shows that much of biologys