EDITORIAL SECTION

Articles

Personalized Medicine and Longevity: Advancing the Frontier

The world is experiencing a profound demographic shift with population aging impacting healthcare economies and human rights The United Nations projects that by the number of people aged and over will double to billion comprising one in six people worldwide United Nations OHCHR By older adults will likely outnumber children necessitating a rethink of health aging and longevity Hartmann Young

Biopharma M&A and Licensing: Strategic Partnerships Fueling Innovation

For much of the last decade acquisitions and licensing agreements were debated in European boardrooms as rival answers to the same question how to refill a pipeline faster than internal research alone allows That framing no longer holds In the most effective pharmaceutical companies run both instruments in parallel choosing between them asset by asset according to scientific maturity geographic o...

Fundamentals of Clinical Pharmacology: Understanding Drug Actions and Ensuring Safety

Clinical pharmacology offers the interface between the philosophies of pharmacology and its application in the actual sense in patient care Fundamentally it is the science which examines the activities of drugs how drugs communicate with biological systems and how such communications result in treatment outcomes or adverse events Clinical pharmacology principles are needed to make sense of how m...

What Are the Implications of the Changing Regulatory Landscape in Europe?

In an age characterized by technological progress changing geopolitical scenarios and an increasing focus on sustainability businesses in Europe are grappling with an intricate network of regulatory shifts

Key Stages in Pharmaceutical Formulation Development: A Complete Guide

One of the most significant operations in the field of drug study is pharmaceutical formulation development to ensure that the medications are distributed to the patients without harm and in the most appropriate manner This is a science that involves the transformation of an active pharmaceutical ingredient API into a solid efficient and convenient dosage form To researchers manufacturers and regu...

Digital Twins in Pharmaceutical R&D: Simulating Biology for Faster Innovation

For most of its modern history pharmaceutical research has been an experimental science with a statistical conscience Build the molecule dose the animal run the trial count the failures and let the survivors pay for everything that did not make it That arrangement has become progressively harder to defend Attrition remains concentrated in the phases where money has already

Techno Trends

Alume Biosciences Secures FDA Breakthrough Therapy Designation for Bevonescein

Alume Biosciences has received Breakthrough Therapy Designation BTD from the US Food and Drug Administration FDA for bevonescein an investigational fluorescent drug being developed to support realtime nerve visualisation during head and neck surgery in adults Bevonescein is an intravenous fluorescent peptidedye conjugate that binds to nerve tissue

Projects

SK pharmteco Plans More Than US$200 Million Investment in Small Molecule and Peptide Manufacturing

SK pharmteco is planning a fiveyear investment of more than US million to expand and modernise its pharmaceutical development and manufacturing operations in the United States The programme will strengthen capabilities for small molecules and peptides while supporting a more

Research Insights

One-month physicochemical stability study of idarubicin prepared in polyolefin-type bags for the treatment of hematological diseases

Idarubicine is a mainstay of the treatment strategy for hematological cancer The literature lacks stability data that comply with current preparation practices and recommendations for conducting stability studies

whitepaper

Post-Translational Modifications in Drug Discovery: From Molecular Regulation to Clinical Impact

For decades the central dogma of molecular biology has anchored our understanding of cellular function DNA to RNA to protein But this linear view is incomplete A growing body of evidence shows that much of biologys