EDITORIAL SECTION

Articles

Global CDMO Expansion: Supporting the Growing Advanced Therapy Pipeline

The European advanced therapy sector has spent the better part of two decades proving a scientific point that engineered cells corrected genes and reprogrammed immune systems can deliver durable clinical benefit That argument is now largely settled The question facing pharmaceutical and biotech leadership is industrial rather than scientific whether these therapies can be manufactured consistentl...

Building Patient-Centric Clinical Trials: Technologies, Strategies, and Regulatory Considerations

Patientcentricity in clinical trials represents a crucial cultural and operational transformation in the development and evaluation of new treatments The patient experience has evolved from a secondary consideration to a central priority in trial design driven by

Renewable Energy Solutions for Pharma Factories: Powering Sustainable Pharmaceutical Manufacturing

One of the most energyconsuming sectors of the industrial sector is the pharmaceutical manufacturing Energy requirement in the pharma factories is continuous and critical whether it is controlled environments and cleanrooms continuous production lines HVAC system cold storage as well as quality testing laboratories With the increasing regulatory pressure ESG undertakings and the cost of energy ren...

Leveraging Blockchain for Drug Traceability and Security in Europe

The area of interest in the pharmaceutical products in the past couple of years has been in the area of traceability and security Recently there has been an increase in fake drugs as well as advanced supply chain management making it difficult to tell the actual quality of the manufactured drugs

Smart Quality Management: AI-Powered GMP Compliance and Release by Exception

European pharmaceutical manufacturing has rarely faced this many simultaneous pressures Tightened sterile expectations have raised the bar across the continents fillfinish capacity biosimilar competition is compressing biologics margins and procurement authorities are pushing

Cell and Gene Therapy's Trillion-Dollar Reckoning Is Here

Cell and gene therapies can cure diseases once thought untreatable Yet a string of commercial collapses now suggests that curing the patient and sustaining the business are two very different challenges and the industry is confronting the gap at last

Techno Trends

Alume Biosciences Secures FDA Breakthrough Therapy Designation for Bevonescein

Alume Biosciences has received Breakthrough Therapy Designation BTD from the US Food and Drug Administration FDA for bevonescein an investigational fluorescent drug being developed to support realtime nerve visualisation during head and neck surgery in adults Bevonescein is an intravenous fluorescent peptidedye conjugate that binds to nerve tissue

Projects

SK pharmteco Plans More Than US$200 Million Investment in Small Molecule and Peptide Manufacturing

SK pharmteco is planning a fiveyear investment of more than US million to expand and modernise its pharmaceutical development and manufacturing operations in the United States The programme will strengthen capabilities for small molecules and peptides while supporting a more

Research Insights

A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG

PIGACDG is a congenital disorder of glycosylation caused by pathogenic partial lossoffunction variants in the PIGA gene PIGA encodes an enzyme responsible for the catalytic transfer of Nacetylglucosamine

whitepaper

Post-Translational Modifications in Drug Discovery: From Molecular Regulation to Clinical Impact

For decades the central dogma of molecular biology has anchored our understanding of cellular function DNA to RNA to protein But this linear view is incomplete A growing body of evidence shows that much of biologys