EDITORIAL SECTION

Articles

What Are the Implications of the Changing Regulatory Landscape in Europe?

In an age characterized by technological progress changing geopolitical scenarios and an increasing focus on sustainability businesses in Europe are grappling with an intricate network of regulatory shifts

The FDA May Be Coming Unannounced to Your Facility: Are You Ready?

On May the President of the United States signed an executive order with far reaching impact on several agencies including the FDA Among other directives beginning in August the US Food and Drug Administration FDA will initiate unannounced inspections at nonUS manufacturing facilities involved in producing drugs biologics medical devices and diagnostics intended for American consumers and patie...

AI-Native R&D: Transforming Drug Discovery Through Intelligent Automation

For four decades pharmaceutical research productivity has moved stubbornly in the wrong direction A new medicine still takes ten to fifteen years to reach patients at a capitalised cost approaching US billion

How AI Is Addressing Drug Development Challenges in Rare Diseases?

Healthcare struggles with persistent obstacles to treat and understand rare diseases which societies call orphan diseases While affecting a minority portion of individuals these rare diseases make therapy discovery difficult because of scarce research data and expensive evaluation costs alongside multifaceted disease pathways The rising use of artificial intelligence AI drives a transformative cha...

Harnessing the Intracellular Machinery to Degrade Cellular Proteins

A countless number of proteins including growth factors receptors and cytokines play a pivotal role during the onset and exacerbation of numerous human diseases including cancer autoimmune and inflammatory disorders Of these proteins extracellular and membraneassociated proteins represent around of human proteome

Pharma Email Marketing Europe: Personalized Campaigns for C-Suite Leads

The pharmaceutical industry is a very competitive industry and to reach the decisionmakers a focused and strategic marketing strategy is necessary Conventional marketing is not often precise enough to reach executives that drive buying alliances and strategic relationships Here the pharma email marketing has come to play as a potent instrument of relationship establishment with the key stakeholder...

Techno Trends

Alume Biosciences Secures FDA Breakthrough Therapy Designation for Bevonescein

Alume Biosciences has received Breakthrough Therapy Designation BTD from the US Food and Drug Administration FDA for bevonescein an investigational fluorescent drug being developed to support realtime nerve visualisation during head and neck surgery in adults Bevonescein is an intravenous fluorescent peptidedye conjugate that binds to nerve tissue

Projects

SK pharmteco Plans More Than US$200 Million Investment in Small Molecule and Peptide Manufacturing

SK pharmteco is planning a fiveyear investment of more than US million to expand and modernise its pharmaceutical development and manufacturing operations in the United States The programme will strengthen capabilities for small molecules and peptides while supporting a more

Research Insights

A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG

PIGACDG is a congenital disorder of glycosylation caused by pathogenic partial lossoffunction variants in the PIGA gene PIGA encodes an enzyme responsible for the catalytic transfer of Nacetylglucosamine

whitepaper

Post-Translational Modifications in Drug Discovery: From Molecular Regulation to Clinical Impact

For decades the central dogma of molecular biology has anchored our understanding of cellular function DNA to RNA to protein But this linear view is incomplete A growing body of evidence shows that much of biologys