App Notes
Optimizing Kinetics Assays to Avoid Avidity Effects
Biosensor-based real time label free interaction analysis using bio-layer interferometry (BLI) has become an indispensable tool in research and development for the selection and production of biologics that target a specific binding partner.
Residual plasmid quantification in gene therapy manufacturing workflows using the QuantStudio Absolute Q Digital PCR System
Residual DNA testing is an established method that is routinely used for the assessment of product quality and safety in the development of gene therapies, vaccines, and similar biotherapeutics.
Efficient gene expression profiling for biomarker identification using multiplex quantitative PCR
Quantitative PCR (qPCR) has long been recognized as a powerful tool for analyzing nucleic acid levels. When combined with reverse transcription of RNA to cDNA before qPCR (RT-qPCR), researchers can sensitively and specifically determine the relative quantities of mRNA transcripts in samples.
High-Throughput Characterization of Brain Organoids Using iQue® HTS Cytometry
Learn how single-cell dissociation and multiparametric marker analysis can be applied to objectively assess brain organoid differentiation in a high-throughput workflow.
Gentle automated organoid transfer and live-cell analysis to improve reproducibility across complex 3D models.
3D organoids and advanced cell models are powerful—but difficult to handle, monitor, and quantify.
Building a unified design-make-test-decide approach to drug discovery
Drug discovery has long followed a core loop: design a molecule, synthesize it, test its biological properties, and analyze the results to inform the next round of design.
Innovative Al Techniques for Accurate Analysis of Cell Morphology and Viability
Accurate segmentation of cell boundaries is the first and most critical step underlying the quantification of cell morphology.
High-Throughput Cytometry for MSC Identity & Differentiation
Accurate assessment of mesenchymal stem cell (MSC) identity and differentiation is essential in both research and clinical applications—especially in the fast-moving field of regenerative medicine.
Achieve Compliance in Ligand Binding Assays with Octet® BLI Systems
Octet® systems enable analytical assessment of biologics in various stages of the development workflow beginning with discovery and early selection to validation, manufacturing and quality control.
High-Throughput Biosimilarity Assessment with Octet® BLI Systems
Demonstrating biosimilarity throughout upstream and downstream production processes is crucial. However, screening all potential candidates using standard analytical methods can be challenging. To overcome this, an alternative high-throughput analytical approach is needed. In this application note, we showcase the ability to rapidly test a Humira® biosimilar (adalimumab) development sample against three key ligands, meeting regulatory requirements.
