AB Sciex\'s breakthrough for therapeutic biologics with CESI-MS
AB Sciex LLC has introduced an innovative technology solution called CESI-MS, revolutionizing biopharmaceutical research and development. This groundbreaking workflow combines Capillary Electrophoresis (CE) and Electrospray Ionization (ESI) technologies, offering a unique and integrated approach for efficient testing, faster time-to-market, and early issue detection.
The CESI-MS system boasts the industry's first commercial ultra low-flow separation and ESI module specifically designed for biologics. It is equipped with a high-performance accurate mass instrument, making it an ideal tool for biopharmaceutical development and drug discovery. This cutting-edge solution is expected to support the development of the industry's next generation of blockbuster products.
By leveraging the CESI-MS approach, biopharmaceutical scientists can achieve superior results compared to traditional liquid chromatography/mass spectrometry methods. Through a single digest and run, users gain comprehensive information including identity, purity, heterogeneity, and stability data, which are vital for biopharmaceutical analysis.
The CE technology seamlessly integrates into the workflows of biopharmaceutical companies, offering fast and efficient separations of intact biologics, automated SDS-Gel, isoelectric focusing, and glycan analysis. This enables thorough characterization and quality control of therapeutic antibodies.
The CESI-MS technology enhances biophysicochemical characterization, providing valuable insights for the development of biologics-based therapeutics. It improves ionization efficiency and reduces ion suppression, resulting in more accurate and reliable data. AB Sciex has developed this robust solution to be user-friendly, eliminating the need for specialized expertise in CE or MS.
Furthermore, the CESI-MS system allows for seamless switching between LC-MS and CESI-MS methods, simplifying the adoption of this innovative technology. The data generated through the CESI-based workflow complements that obtained from LC-MS/MS solutions, offering a comprehensive analysis platform for biopharmaceutical research and development.
