Thin Films As An Emerging Platform For Drug Delivery
Authors: Sandeep Karki, Hyeongmin Kim, Seon-Jeong Na, Dohyun Shin, Kanghee Jo, Jaehwi Lee
Abstract:
Pharmaceutical researchers worldwide are actively investigating the potential of thin films as an innovative approach to drug delivery. These films offer an alternative to traditional dosage forms and are known for their convenience in swallowing, self-administration, and fast dissolution. With their versatile characteristics, thin films serve as a promising platform for drug delivery, facilitating both systemic and localized action through various routes such as oral, buccal, sublingual, ocular, and transdermal administration.
Developing effective thin films necessitates a comprehensive understanding of the pharmacological and pharmaceutical properties of drugs and polymers, as well as the careful selection of manufacturing processes. This review aims to provide an overview of the key factors that influence the formulation of thin films. It covers aspects such as the physicochemical properties of polymers and drugs, anatomical and physiological considerations, characterization methods, and quality specifications. By addressing these factors, the challenges associated with formulation design can be overcome.
Furthermore, this review sheds light on recent trends and perspectives in thin film product development, showcasing the advancements made by various companies in this field.
Keywords
Thin film; Film-forming polymer; Mechanical properties; Manufacturing; Characterization
Citation: Sandeep Karki, Hyeongmin Kim, Seon-Jeong Na, Dohyun Shin, Kanghee Jo, Jaehwi Lee Thin Films As An Emerging Platform For Drug Delivery http://dx.doi.org/10.1016/j.ajps.2016.05.004
Received: 21 April 2016, Accepted: 12 May 2016, Available online: 6 June 2016
Copyright: © 2016 © Elsevier B.V. or its licensors or contributors. Open Access funded by Shenyang Pharmaceutical University
Conflict of interest
The authors declare no conflict of interest.
Acknowledgements
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2015R1A5A1008958). This work was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2015R1D1A1A02062278).
