Vittoria Biotherapeutics Announces Dosing of First Patient in Phase 1 Clinical Trial of VIPER-101
Friday, December 20, 2024
Vittoria Biotherapeutics, Inc., a clinical-stage immunotherapy company specializing in the development of innovative cell therapies for hard-to-treat diseases, today announced that in November, the first patient was dosed in its Phase 1 clinical trial of VIPER-101. VIPER-101 is an enabled autologous cell therapy designed to treat relapsed and/or refractory (r/r) T cell lymphoma, a severe disease with limited treatment options.
VIPER-101 incorporates Vittoria’s proprietary Senza5™ platform which integrates CD5 gene-editing technology with a rapid, 5-day manufacturing process to deliver a potent and targeted therapy for r/r T cell lymphoma. This innovative approach is intended to enhance the efficacy and safety profile of conventional autologous cell therapies, offering new hope to patients whose cancers have not responded to traditional lines of treatment.
“This milestone represents a pivotal step forward in our mission to develop transformative therapies for patients with difficult-to-treat diseases,” said Nicholas Siciliano, Ph.D., Chief Executive Officer of Vittoria Biotherapeutics. "By addressing the key limitations of existing CAR-T therapies, VIPER-101 is uniquely engineered to enhance the potency, durability, and safety of treatment. We are eager to evaluate its therapeutic potential and look forward to generating meaningful data that could redefine the treatment paradigm for patients battling T cell lymphoma.”
Marco Ruella, M.D., Scientific Founder of Vittoria Biotherapeutics and a Physician-Scientist in the Perelman School of Medicine at the University of Pennsylvania added, “Despite advances in cell therapy, patients with T cell lymphoma continue to have limited treatment options. Bringing this innovative approach into the clinic represents the culmination of years of dedicated research aimed at addressing the need for new treatment options for these patients.”
The open-label Phase 1 study is designed to assess safety and preliminary efficacy, and to determine the recommended Phase 2 dose (RP2D) of VIPER-101 in patients with r/r CD5 positive nodal T cell non-Hodgkin lymphoma (NHL). The study is currently recruiting patients and additional information can be found at ClinicalTrials.gov (NCT06420089).
The Company anticipates preliminary data from the trial in 2025.
Source: globenewswire.com
