Pharma Focus Europe

Singleron Unveils AccuraSCOPE® Single-Cell Transcriptome Technology

Wednesday, January 31, 2024

Singleron Biotechnologies, a leading player in single-cell multi-omic solutions for precision medicine, has introduced two innovative products: the AccuraSCOPE® Single Cell Transcriptome and Genome Library Kit, and the AccuraSCOPE® Single Cell Full-Length Transcriptome Library Kit.

The AccuraSCOPE Single Cell Transcriptome and Genome Library Kit represent a significant advancement in single-cell multi-omic analysis, allowing for the simultaneous profiling of the entire genome and transcriptome. This groundbreaking method goes beyond single-cell RNA sequencing, enabling deep single-cell genome sequencing by amplifying minute DNA quantities from individual cells. This capability facilitates the comprehensive detection of single nucleotide variants and chromosomal aberrations at the single-cell level. Using proprietary bead-based technology, the kit captures both genomic DNA and mRNA from each cell, converting them into high-quality sequencing libraries. The integrated analysis of a cell's transcriptome and genome provides a comprehensive understanding of cellular heterogeneity in normal development and disease. With a multiplex design and streamlined workflow, the kit allows for single-cell mRNA and DNA library preparation from up to 384 single cells in parallel within a single day, significantly reducing time and costs.

The AccuraSCOPE Single Cell Full-Length Transcriptome Library Kit is another addition to the AccuraSCOPE portfolio, enhancing the toolkit by offering full-length, comprehensive, and rapid RNA sequencing library preparation. This kit enables the detection of alternative splicing at the single-cell level, substantially reducing hands-on time compared to existing full-length single-cell RNAseq methods.

Tailored to support clinical researchers in oncology, gene and cell therapy, immunology, and reproductive biology, these innovations empower accurate detection of genomic and transcriptomic changes. This capability reveals the relationship between genomic dynamics and gene expression profiles, providing insights into the functional impact of point mutations and copy number variations.

To address customers' data analysis needs with the new AccuraSCOPE products, Singleron has developed two bioinformatic analysis pipelines. The RNA sequencing data analysis pipeline covers the entire workflow from FASTQ files to a count matrix, while the DNA data analysis pipeline starts with FASTQ files and includes variance calling and variant annotation.



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