Oxford Nanopore Technologies and Twist Bioscience Partner to Introduce Beta Program for Advancing Personalized Medicine via Pharmacogenomics
Thursday, May 23, 2024
Today, Oxford Nanopore Technologies announced the launch of a new Pharmacogenomics (PGx) Beta Program aimed at advancing personalized medicine. This program combines Twist Bioscience’s next-generation sequencing (NGS) target enrichment technology with Oxford Nanopore’s sequencing platform.
The newly unveiled Twist-Oxford Nanopore long-read PGx solution is now available for research use. It is designed to provide unambiguous genetic results in a single end-to-end workflow from sample to PGx star allele call, eliminating the need for time-consuming and costly follow-up tests compared to conventional methods. The beta program aims to increase the diversity of genetic variants evaluated by Oxford Nanopore’s platform.
Oxford Nanopore, expressed the company’s commitment to advancing personalized medicine through PGx by providing clear genetic results in a single assay. Sanghera highlighted the collaboration with Twist Bioscience and the value proposition for PGx offered by Oxford Nanopore's platform, including long reads, ultra-fast sequencing speed, accessible form factor, and flexibility in throughput.
The PGx beta program has successfully achieved full resolution of the CYP2D6 gene in a single assay. CYP2D6 is responsible for metabolizing 20% of drugs on the market and is one of the most challenging genes to sequence due to its complex structure. The Twist Alliance Long-Read PGx Panel coupled with Chinook, Oxford Nanopore’s CYP2D6-specific allele caller, demonstrated 100% CYP2D6 reference concordance, overcoming the limitations of conventional sequencing technologies.
Twist Bioscience, emphasized the potential of the collaboration to expand the reach of NGS products and provide researchers with tools for developing personalized therapies. Leproust highlighted the exceptional uniformity of Twist’s sequencer-agnostic workflows in advancing scientific breakthroughs globally.
Source: businesswire.com
