Addex and Indivior Extend Research Term of Substance Use Disorder GABAB Positive Allosteric Modulator Discovery Collaboration
Friday, December 09, 2022
Addex Therapeutics, a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug discovery and development, today announced that the research term of its collaboration agreement with Indivior PLC (LON: INDV) for the discovery of novel oral gamma-aminobutyric acid subtype B (GABAB) positive allosteric modulator (PAM) drug candidates for the treatment of substance use disorder has been extended until June 30, 2023. As part of the amended agreement, Indivior will pay Addex an additional USD 1 million to cover additional research activities during this extended period. Addex retains exclusive rights to develop its own independent GABAB PAM program and is advancing compounds in Charcot-Marie-Tooth type 1A neuropathy (CMT1A), chronic cough and pain.
“This additional research funding reflects the progress being made in our GABAB PAM research collaboration with Indivior as we evaluate novel compounds for entry into IND enabling studies for Indivior’s program in substance use disorder as well as our internal program for CMT1A, chronic cough and pain,” said Mikhail Kalinichev, Head of Translational Science of Addex. “GABAB PAM is a highly validated mechanism of action in these disease areas, which holds significant promise to bring important benefit to the quality of life of patients.”
“Indivior continues to be an important strategic partner for Addex as we continue to progress our preclinical portfolio towards the clinic and advance discussions with potential partners across our portfolio,” said Tim Dyer, CEO of Addex. “In addition to the progress made with Indivior, we anticipate a decision by Janssen in Q1 2023 on moving ADX71149 further into clinical development based on results from the first part of a Phase 2 study in epilepsy.”
