Pharma Focus Europe

AC Immune Partner Life Molecular Imaging Initiates Phase 3 Study of Tau PET Diagnostic PI-2620 for Alzheimer’s Disease

Thursday, January 19, 2023

AC Immune SA, a clinical-stage biopharmaceutical company pioneering precision medicine for neurodegenerative diseases, today announced that its collaboration partner, Life Molecular Imaging (LMI), has imaged the first patient in ADvance, the pivotal Phase 3 trial of PI-2620, a Tau PET (positron emission tomography) imaging agent for AD (Alzheimer’s disease). PI-2620 was discovered in collaboration between AC Immune and LMI and is developed under a strategic collaboration and exclusive licensing agreement with LMI.

Dr. Andrea Pfeifer, Chief Executive Officer of AC Immune SA, commented: “We are delighted to see LMI launching this pivotal Phase 3 trial of PI-2620, our next generation, potentially best-in-class Tau PET tracer. The ability to detect and quantify aggregated Tau with enhanced sensitivity and specificity, will improve our diagnostic confidence and accelerate clinical development of therapeutic interventions. This development underscores the strength of our Morphomer® platform which continues to generate excellent candidates against multiple pathological proteins involved in neurodegenerative diseases.”

This histopathology study’s objective is to confirm the tracer’s safety, diagnostic efficacy and accuracy in detecting and staging Tau pathology of PI-2620 before seeking market approval. The decision to advance PI-2620 into Phase 3 development in AD was supported by Phase 2 results presented at this year’s Alzheimer’s Association International Conference (AAIC)1.

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