Rapid & Efficient Screening of Primary B Cells to Identify Target-Specific Antibodies

Rapid and efficient screening of primary B cells enables the identification of highly specific antibodies using advanced microfluidic picodroplet technology. The automated single-cell workflow supports encapsulation, screening, sorting, imaging, and dispensing of antibody-secreting cells with high sensitivity and throughput. This approach accelerates antibody discovery, preserves cell viability and native antibody pairing, and allows rapid identification of high-affinity antibodies from human and rodent samples for downstream therapeutic and functional analysis.

Key insights of this Application Note:

• High-throughput screening of millions of primary B cells.
• Automated single-cell encapsulation and analysis workflow.
• Enhanced cell viability with sensitive picodroplet technology.
• Rapid identification of high-affinity target-specific antibodies.